Larkins Nicholas, Murray Kevin J
Rheumatology Department, Princess Margaret Hospital, Perth, Western Australia, Australia.
J Paediatr Child Health. 2013 Feb;49(2):144-7. doi: 10.1111/jpc.12094. Epub 2013 Jan 28.
Primary chilblains are an idiopathic cold-induced vasculopathy affecting the soft tissues of the hands and feet. Secondary chilblains occur in different forms of vasculitis and chronic autoimmune connective tissue disorders. Idiopathic chilblains are rarely reported in children and may generate significant anxiety to doctors and patients. We describe a cluster of idiopathic chilblains encountered over the winter of 2010 in Perth, Western Australia.
This is a retrospective review of patients identified from a prospectively compiled database of all new cases seen in our department. Data on history, examination, investigations, prescribed treatments and outcomes were collected.
Thirty-two patients with isolated idiopathic chilblains were included, including 20 females and 12 males with a median age at onset of 13.5 years. Lesions were papular with signs of peripheral vasoconstriction causing acrocyanosis, and uncomfortable due to pain and/or pruritis in most. Thickening of the small joints was common where lesions involved these areas. Ulceration of lesions also occurred in some. One patient required hospitalisation for secondary bacterial infection. Most received some form of treatment including non-steroidal anti-inflammatory drugs, prednisolone or nifedipine. Most patients improved spontaneously with warmer weather or responded to cold protection advice. All had resolved completely by late spring (November).
Our cluster of chilblains was associated with an unusually cold winter in Perth 2010. It is the largest series reported in the literature, suggesting that chilblains may be more common than previously thought. Chilblains are almost always benign in nature and patients are systemically well and usually need no further investigation and only symptomatic treatment. Prompt recognition can avoid excessive investigation and anxiety, allowing appropriate simple advice and treatment.
原发性冻疮是一种特发性冷诱导血管病,累及手足软组织。继发性冻疮发生于不同形式的血管炎和慢性自身免疫性结缔组织疾病。特发性冻疮在儿童中鲜有报道,可能会给医生和患者带来极大的焦虑。我们描述了2010年冬季在澳大利亚西部珀斯遇到的一组特发性冻疮病例。
这是一项对从我们科室前瞻性汇编的所有新病例数据库中识别出的患者进行的回顾性研究。收集了病史、检查、检验、所开治疗方法及治疗结果等数据。
纳入32例孤立性特发性冻疮患者,其中女性20例,男性12例,发病中位年龄为13.5岁。皮损为丘疹性,伴有外周血管收缩导致的肢端青紫体征,多数因疼痛和/或瘙痒而不适。皮损累及小关节部位时,小关节增厚很常见。部分皮损也出现溃疡。1例患者因继发细菌感染需住院治疗。多数患者接受了某种形式的治疗,包括非甾体抗炎药、泼尼松龙或硝苯地平。多数患者在天气转暖后自行好转,或对防寒建议有反应。到春末(11月)时所有患者均已完全痊愈。
我们的这组冻疮病例与2010年珀斯异常寒冷的冬季有关。这是文献报道中最大的一组病例系列,表明冻疮可能比之前认为的更为常见。冻疮本质上几乎总是良性的,患者全身状况良好,通常无需进一步检查,仅需对症治疗。及时识别可避免过度检查和焦虑,给予适当的简单建议和治疗。