Department of Gastroenterology, Peking University Third Hospital, Beijing, China.
J Dig Dis. 2013 Jun;14(6):299-304. doi: 10.1111/1751-2980.12040.
This study aimed to investigate the efficacy of fluorescence spectroscopy of gastric juice for early gastric cancer (EGC) screening.
Gastric juice was collected from 101 participants who underwent endoscopy in the Outpatient Endoscopy Center of Peking University Third Hospital. The participants were divided into three groups: the normal mucosa or chronic non-atrophic gastritis (NM-CNAG) group (n = 35), advanced gastric cancer (AGC) group (n = 33) and EGC group (n = 33). Fluorescence spectroscopic analysis was performed in all the gastric juice samples and the maximum fluorescence intensity of the first peak (P1 FI) was measured.
The mean fluorescence intensity of P1 FI of gastric juice in AGC (92.1 ± 10.7) and EGC (90.8 ± 12.0) groups was significantly higher than that in the NM-CNAG group (55.7 ± 7.5) (AGC vs NM-CNAG, P = 0.006 and EGC vs NM-CNAG, P = 0.015, respectively). The areas under the receiver operating characteristic curves for the detection of AGC and EGC were 0.681 (95% confidence interval [CI] 0.553-0.810, P = 0.010) and 0.655 (95% CI 0.522-0.787, P = 0.028). With the P1 FI of ≥47.7, the sensitivity, specificity and accuracy for detecting EGC were 69.7%, 57.1% and 63.2%, respectively.
The enhancement of P1 FI of gastric juice occurs at the early stage of gastric cancer. Fluorescence spectroscopy of gastric juice may be used as a novel screening tool for the early detection of gastric cancer.
本研究旨在探讨胃液荧光光谱法在早期胃癌（EGC）筛查中的应用效果。
收集北京大学第三医院门诊内镜中心 101 例患者的胃液。患者分为三组：正常黏膜或慢性非萎缩性胃炎（NM-CNAG）组（n=35）、进展期胃癌（AGC）组（n=33）和 EGC 组（n=33）。对所有胃液样本进行荧光光谱分析，并测量第一峰（P1 FI）的最大荧光强度。
AGC（92.1±10.7）和 EGC（90.8±12.0）组胃液 P1 FI 的平均荧光强度明显高于 NM-CNAG 组（55.7±7.5）（AGC 与 NM-CNAG 相比，P=0.006；EGC 与 NM-CNAG 相比，P=0.015）。检测 AGC 和 EGC 的受试者工作特征曲线下面积分别为 0.681（95%置信区间 [CI] 0.553-0.810，P=0.010）和 0.655（95%CI 0.522-0.787，P=0.028）。当 P1 FI 大于等于 47.7 时，检测 EGC 的敏感性、特异性和准确性分别为 69.7%、57.1%和 63.2%。
胃癌早期 P1 FI 增强。胃液荧光光谱法可能成为胃癌早期检测的一种新的筛查工具。
