Bruker BioSpin AG, Faellanden, Switzerland.
Bone. 2013 May;54(1):44-7. doi: 10.1016/j.bone.2013.01.027. Epub 2013 Jan 26.
This paper reports a proof of principle of direct depiction of trabecular bone microstructure in vitro by means of magnetic resonance imaging (MRI). Such depiction is achieved by (1)H imaging of water embedded in the bone matrix. The fast transverse relaxation of this compartment with T2(⁎) on the order of a few hundreds of microseconds is addressed by a three-dimensional MRI technique with zero echo time (ZTE). ZTE imaging at an isotropic spatial resolution of 56 μm is demonstrated in a trabecular bone specimen extracted from a bovine bone. In the MR images, the trabecular bone structure is clearly depicted and a high level of robustness against off-resonance artefacts is observed. The structural accuracy of the MR data is investigated by comparison with x-ray micro-computed tomography.
本文报告了一种通过磁共振成像（MRI）直接描绘体外小梁骨微观结构的原理证明。这种描绘是通过（1）H 对嵌入骨基质中的水成像来实现的。通过具有零回波时间（ZTE）的三维 MRI 技术解决了该隔室的快速横向弛豫，T2（⁎）约为几百微秒。在从牛骨中提取的小梁骨标本中，展示了具有 56 μm 各向同性空间分辨率的 ZTE 成像。在 MR 图像中，小梁骨结构清晰可见，并观察到对离频伪影具有很高的稳健性。通过与 X 射线微计算机断层扫描（micro-CT）比较，研究了 MR 数据的结构准确性。
