视网膜色素变性且视力良好患者的对比敏感度和色觉：与频域光学相干断层扫描结果的相关性

Contrast sensitivity and color vision in eyes with retinitis pigmentosa and good visual acuity: correlations with SD-OCT findings.

作者信息

Yioti Georgia G, Kalogeropoulos Chris D, Aspiotis Miltiadis B, Stefaniotou Maria I

机构信息

Department of Ophthalmology, University of Ioannina School of Medicine, Ioannina, Greece.

出版信息

Ophthalmic Surg Lasers Imaging. 2012 Nov-Dec;43(6 Suppl):S44-53. doi: 10.3928/15428877-20121001-07.

DOI:10.3928/15428877-20121001-07

PMID:23357324

Abstract

BACKGROUND AND OBJECTIVE

To investigate the morphological substrate of the changes in visual function in eyes with retinitis pigmentosa and good visual acuity using spectral-domain optical coherence tomography (SD-OCT).

PATIENTS AND METHODS

A total of 30 eyes of 17 patients with retinitis pigmentosa and visual acuity of 20/40 or better underwent contrast sensitivity and color vision testing. The retinal thickness at the fovea and macula and the length of the photoreceptor inner/outer segment (IS/OS) junction were assessed by SD-OCT. Structural-functional correlations were investigated.

RESULTS

Contrast sensitivity correlated well with IS/OS length (Spearman r = 0.719, P < .001) and foveal thickness (r = 0.672, P < .001) and moderately with macular thickness (r = 0.422, P = .025). Moreover, color vision correlated significantly with IS/OS length (r = -0.725, P < .001) and foveal thickness (r = -0.661, P < .001).

CONCLUSION

In eyes with retinitis pigmentosa and good visual acuity, the structural changes observed on OCT scans correspond well to subtle measures of central visual function, complementary to visual acuity testing.

摘要

背景与目的

使用光谱域光学相干断层扫描（SD - OCT）研究视力良好的视网膜色素变性患者眼部视觉功能变化的形态学基础。

患者与方法

17例视网膜色素变性患者的30只眼，视力为20/40或更好，接受了对比敏感度和色觉测试。通过SD - OCT评估黄斑中心凹和黄斑处的视网膜厚度以及光感受器内/外节（IS/OS）连接的长度。研究结构与功能的相关性。

结果

对比敏感度与IS/OS长度（Spearman r = 0.719，P <.001）和黄斑中心凹厚度（r = 0.672，P <.001）相关性良好，与黄斑厚度中度相关（r = 0.422，P =.025）。此外，色觉与IS/OS长度（r = -0.725，P <.001）和黄斑中心凹厚度（r = -0.661，P <.001）显著相关。