Department of Pediatrics, Rothman Center for Neuropsychiatry, University of South Florida, St. Petersburg, FL 33701, USA.
J Am Acad Child Adolesc Psychiatry. 2013 Feb;52(2):132-142.e2. doi: 10.1016/j.jaac.2012.11.007. Epub 2013 Jan 2.
To examine the efficacy of a modular cognitive-behavioral therapy (CBT) protocol relative to treatment as usual (TAU) among children with high-functioning autism spectrum disorders (ASD) and clinically significant anxiety.
A total of 45 children (7-11 years of age) with high-functioning ASD and clinically significant anxiety were randomized to receive 16 sessions of weekly CBT or TAU for an equivalent duration. After screening, assessments were conducted at baseline, post-treatment, and 3-month follow-up. Raters were blind to treatment condition.
Youth receiving CBT showed substantial improvement relative to TAU on primary anxiety outcomes. Of 24 children randomized to the CBT arm, 18 (75%) were treatment responders, versus only 3 of 21 children (14%) in the TAU arm. Gains were generally maintained at 3-month follow-up for CBT responders.
Relative to usual care, CBT adapted for anxious youth with high-functioning ASD demonstrates large effects in reducing anxiety symptoms. This study contributes to the growing literature supporting adapted CBT approaches for treating anxiety in youth with ASD.
研究针对高功能自闭症谱系障碍（ASD）和临床显著焦虑儿童的模块化认知行为疗法（CBT）方案相对于常规治疗（TAU）的疗效。
共有 45 名（7-11 岁）具有高功能 ASD 和临床显著焦虑的儿童被随机分配接受每周 16 次的 CBT 或 TAU，持续时间相同。在筛选后，在基线、治疗后和 3 个月随访时进行评估。评估者对治疗条件不知情。
与 TAU 相比，接受 CBT 的青少年在主要焦虑结果上表现出显著改善。在被随机分配到 CBT 组的 24 名儿童中，18 名（75%）为治疗应答者，而在接受 TAU 组的 21 名儿童中，只有 3 名（14%）为治疗应答者。对于 CBT 应答者，收益通常在 3 个月随访时保持。
与常规护理相比，针对高功能 ASD 焦虑青少年的适应性 CBT 方案在降低焦虑症状方面显示出显著效果。这项研究为支持针对 ASD 青少年焦虑的适应性 CBT 方法的不断增加的文献做出了贡献。
