Guy's Hospital, Guy's & St Thomas NHS Foundation Trust, Great Maze Pond, London SE1 9RT, United Kingdom.
Guy's Hospital, Guy's & St Thomas NHS Foundation Trust, Great Maze Pond, London SE1 9RT, United Kingdom; Section of Research Oncology, Division of Cancer Studies, King's College London, Guy's Hospital, Great Maze Pond, London SE1 9RT, United Kingdom.
Breast. 2013 Apr;22(2):194-196. doi: 10.1016/j.breast.2013.01.003. Epub 2013 Jan 26.
Pleomorphic Lobular Carcinoma in Situ (PLCIS) is a pathological variant of Lobular Carcinoma in Situ (LCIS) with distinct features. Since first described over a decade ago there are only few papers published about this condition.
Medline and Pubmed based literature overview was done with the aim of describing the different histopathological, radiological and clinical features of this pathological entity to highlight the different clinicopathological presentations and modalities of treatment described.
PLCIS has different biological features when compared to LCIS. It is more likely to be associated with invasive disease and the immuno-histochemical profile shows it is less likely to be ER and PR positive with higher positivity of HER2, Ki-67and p53. It has been suggested that PLCIS should be treated more aggressively than LCIS and surgically excised in similar fashion to DCIS.
PLCIS is a more aggressive variant of LCIS that needs to be managed differently. Surgical excision with clear margins is advised. Further adjuvant treatments have been described in the literature with little evidence to support their use.
多形性小叶原位癌（PLCIS）是小叶原位癌（LCIS）的一种具有独特特征的病理变异。自十多年前首次描述以来，仅有少数几篇关于这种情况的论文发表。
通过 Medline 和 Pubmed 进行文献综述，旨在描述这种病理实体的不同组织病理学、影像学和临床特征，以突出描述的不同临床病理表现和治疗方式。
与 LCIS 相比，PLCIS 具有不同的生物学特征。它更有可能与浸润性疾病相关，免疫组织化学特征显示其 ER 和 PR 阳性率较低，而 HER2、Ki-67 和 p53 阳性率较高。有人认为，PLCIS 的治疗应该比 LCIS 更具侵袭性，并且应该以类似于 DCIS 的方式进行手术切除。
PLCIS 是 LCIS 的一种侵袭性更强的变异型，需要采用不同的治疗方法。建议进行有明确切缘的手术切除。文献中还描述了其他辅助治疗方法，但几乎没有证据支持其使用。
