Gomi H, Inui K, Taniguchi H, Yoshikawa Y, Yamanouchi K
Laboratory Animal Research Center, University of Tokyo, Japan.
J Neuropathol Exp Neurol. 1990 May;49(3):250-9. doi: 10.1097/00005072-199005000-00006.
The pathogenesis of progressive spongy degeneration in zitter rats with genetic spongiform encephalopathy was examined histopathologically and biochemically in the context of edematous change in the central nervous system (CNS). Histopathological studies revealed that vacuolation in the CNS of zitter rats progressed with aging and the severity of spongy degeneration was markedly divergent in different areas in the CNS. Edematous change was confirmed by a consistently higher water content in the brain of zitter rats than in that of normal SD/J rats at all ages. Furthermore, a close relationship between spongy degeneration and edematous change in the CNS was demonstrated by regional measurement of specific gravity (SPGR) of brain tissues and quantification of the spongy degeneration by computer-image analysis. The brain regions with lighter SPGR were more severely affected by spongy degeneration. These results suggest that edematous change is related to the pathogenesis of spongy degeneration in the CNS of the zitter rat.
在伴有遗传性海绵状脑病的颤抖鼠中，在中枢神经系统（CNS）水肿变化的背景下，对进行性海绵状变性的发病机制进行了组织病理学和生物化学检查。组织病理学研究表明，颤抖鼠中枢神经系统中的空泡化随年龄增长而进展，并且海绵状变性的严重程度在中枢神经系统的不同区域明显不同。通过在所有年龄段，颤抖鼠大脑中的含水量始终高于正常SD/J大鼠，证实了水肿变化。此外，通过脑组织比重（SPGR）的区域测量和计算机图像分析对海绵状变性进行定量，证明了中枢神经系统中海绵状变性与水肿变化之间的密切关系。SPGR较轻的脑区受海绵状变性的影响更严重。这些结果表明，水肿变化与颤抖鼠中枢神经系统中海绵状变性的发病机制有关。
