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A new rat mutant with defective overhairs and spongy degeneration of the central nervous system: clinical and pathologic studies.

作者信息

Rehm S, Mehraein P, Anzil A P, Deerberg F

出版信息

Lab Anim Sci. 1982 Feb;32(1):70-3.

PMID:7078076
Abstract

A new spontaneous autosomal recessive mutation with a nervous disorder and a hair anomaly occurred in a colony of Sprague Dawley rats. The animals developed a generalized body tremor at about 15 days of age, and with increasing age a progressive flaccid paresis occurred. Light microscopy revealed spongy changes in the central nervous system. The mutant was designated zitter rat (zi).

摘要

相似文献

1
A new rat mutant with defective overhairs and spongy degeneration of the central nervous system: clinical and pathologic studies.
Lab Anim Sci. 1982 Feb;32(1):70-3.
2
Sprague Dawley rat mutant with tremor, ataxia, tonic immobility episodes, epilepsy and paralysis.患有震颤、共济失调、强直性静止发作、癫痫和瘫痪的斯普拉格-道利大鼠突变体。
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3
Assignment of tremulous body mutant gene zitter (zi) to linkage group IV of the rat (Rattus norvegicus).
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Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system.吸引蛋白/红木蛋白/颤抖蛋白在中枢神经系统的髓鞘形成中起关键作用。
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[Tremor and crooked whiskers and body hair found in Kyo:Wister rats].
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Characteristics of a new hairless mutation (bald) in rats.
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Epileptic seizures in rats homozygous for two mutations, zitter and tremor.
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Edematous changes in the central nervous system of zitter rats with genetic spongiform encephalopathy.患有遗传性海绵状脑病的颤抖大鼠中枢神经系统的水肿变化。
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Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system.吸引蛋白/红木蛋白/颤抖蛋白在中枢神经系统的髓鞘形成中起关键作用。
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):559-64. doi: 10.1073/pnas.98.2.559.