Tierney G, Wilkinson M J, Jones J S
Department of Histopathology, University Hospital, Nottingham, U.K.
J Pathol. 1990 Mar;160(3):209-11. doi: 10.1002/path.1711600305.
The ploidy of a series of pleural lesions--reactive proliferations, malignant mesotheliomas and metastatic tumours--was measured on a Leitz Miamed DNA image analyser using Feulgen-stained slides. The technique successfully recognized all the metastatic tumours as malignant; this corresponds to previous work. However, it was not successful in classifying mesothelial lesions as benign or malignant, resulting in a very high false-negative rate and a moderately high false-positive rate. Mesothelial lesions appear to have a wide range of ploidy values irrespective of their biological behaviour. Thus, for primary mesothelial tumours, the ploidy value cannot be used as a reliable diagnostic index.
使用Feulgen染色玻片，在Leitz Miamed DNA图像分析仪上测量了一系列胸膜病变——反应性增生、恶性间皮瘤和转移性肿瘤的倍性。该技术成功地将所有转移性肿瘤识别为恶性肿瘤；这与先前的研究结果一致。然而，在将间皮病变分类为良性或恶性方面并不成功，导致假阴性率非常高，假阳性率也适中偏高。无论其生物学行为如何，间皮病变似乎都有广泛的倍性值。因此，对于原发性间皮瘤，倍性值不能用作可靠的诊断指标。
