Naukkarinen A, Syrjänen K J
Department of Pathology, University of Kuopio, Finland.
J Pathol. 1990 Mar;160(3):217-22. doi: 10.1002/path.1711600307.
Inflammatory infiltrates were analysed in tissue sections of 76 breast carcinomas by counting the percentage of macrophages, IgA+ and IgG+ plasma cells, T cells with their subpopulations, and natural killer cells, and by measuring postcapillary venules (PCVs, found in 12 cases) within the infiltrates. These parameters were correlated with nuclear grade and biochemically determined hormone receptor status, known markers of tumour differentiation. A direct correlation was found between the extent of inflammation and nuclear grade (P less than 0.0001), and an inverse correlation between inflammation and oestrogen receptor (OR) positivity (P less than 0.05) as well as inflammation and progesterone receptor (PR) positivity (P less than 0.05). The percentage of the OKT8+ suppressor/cytotoxic T cells increased when the inflammation expanded from scanty to moderate (P less than 0.02). The diameter of the PCVs also increased with increasing inflammatory infiltrate (P less than 0.02). In addition, a direct correlation exists between the diameter of the PCVs and both the percentage of the OKT8+ T cells (P less than 0.04) and the Leu-7+ natural killer cells (P less than 0.03).
通过计数巨噬细胞、IgA+和IgG+浆细胞、T细胞及其亚群以及自然杀伤细胞的百分比，并测量浸润灶内的毛细血管后微静脉（PCV，12例中发现），对76例乳腺癌组织切片中的炎性浸润进行分析。这些参数与核分级以及生化测定的激素受体状态相关，而核分级和激素受体状态是肿瘤分化的已知标志物。发现炎症程度与核分级之间存在直接相关性（P<0.0001），炎症与雌激素受体（OR）阳性之间存在负相关性（P<0.05），炎症与孕激素受体（PR）阳性之间也存在负相关性（P<0.05）。当炎症从稀少发展到中度时，OKT8+抑制/细胞毒性T细胞的百分比增加（P<0.02）。PCV的直径也随着炎性浸润的增加而增大（P<0.02）。此外，PCV的直径与OKT8+T细胞的百分比（P<0.04）和Leu-7+自然杀伤细胞的百分比（P<0.03）之间均存在直接相关性。
