Guven Aytekin, Caliskan Mustafa, Ciftci Ozgur, Barutcu Irfan
Department of Cardiology, Baskent University School of Medicine, Konya, Turkey.
Blood Coagul Fibrinolysis. 2013 Mar;24(2):170-4. doi: 10.1097/MBC.0b013e32835aba36.
Masked hypertension is associated with an increase in cardiovascular risk. Mean platelet volume (MPV), a determinant of platelet function, is a new risk factor for atherothrombosis. High-sensitive C-reactive protein (CRP) is an exquisitely sensitive systemic marker of inflammatory response. We designed this study to evaluate MPV and CRP in masked hypertensive patients and to compare those with essential hypertensive and healthy normotensive individuals. Forty-two untreated masked hypertensive patients, 53 untreated essential hypertensive patients and age-sex matched 37 normotensive healthy individuals were included in the study. Blood samples were collected and haematological parameters were measured. Plasma CRP level was measured by immunonephelometery method. The MPV was significantly higher in masked hypertensive (8.8 ± 1.6 fl) and essential hypertensive patients (9.1 ± 1.7 fl) than those of normotensive control individuals (7.8 ± 0.8 fl) (P = 0.01 and P = 0.003, respectively), whereas there was no significant difference between the masked hypertensive and essential hypertensive individuals (P > 0.05). CRP levels were also significantly higher in masked hypertensive patients than in normotensives individuals (3.31 ± 1.70, 1.98 ± 1.56 mg/l, P < 0.001, respectively). There was a significant positive correlation between MPV and CRP levels (P < 0.001, r = 0.850) in masked hypertensive patients. Patients with masked hypertension have higher MPV and CRP values than controls. Increased MPV and CRP levels may be the possible mechanisms behind the increased cardiovascular risk in masked hypertensive patients.
隐匿性高血压与心血管风险增加相关。平均血小板体积（MPV）作为血小板功能的一个决定因素，是动脉粥样硬化血栓形成的一个新的危险因素。高敏C反应蛋白（CRP）是炎症反应的一种极其敏感的全身标志物。我们设计本研究以评估隐匿性高血压患者的MPV和CRP，并将其与原发性高血压患者和健康血压正常个体进行比较。本研究纳入了42例未经治疗的隐匿性高血压患者、53例未经治疗的原发性高血压患者以及年龄和性别匹配的37例血压正常的健康个体。采集血样并测量血液学参数。采用免疫比浊法测量血浆CRP水平。隐匿性高血压患者（8.8±1.6 fl）和原发性高血压患者（9.1±1.7 fl）的MPV显著高于血压正常的对照个体（7.8±0.8 fl）（P分别为0.01和0.003），而隐匿性高血压患者和原发性高血压患者之间无显著差异（P>0.05）。隐匿性高血压患者的CRP水平也显著高于血压正常个体（分别为3.31±1.70、1.98±1.56 mg/l，P<0.001）。隐匿性高血压患者的MPV和CRP水平之间存在显著正相关（P<0.001，r=0.850）。隐匿性高血压患者的MPV和CRP值高于对照组。MPV和CRP水平升高可能是隐匿性高血压患者心血管风险增加背后的潜在机制。
