一项比较吸入氧 30%与 80%时对剖宫产手术部位感染影响的随机对照试验。
Randomized controlled trial of the effect of 30% versus 80% fraction of inspired oxygen on cesarean delivery surgical site infection.
机构信息
Departments of Obstetrics and Gynecology, Wright State University and Miami Valley Hospital, Dayton, Ohio.
出版信息
Am J Perinatol. 2013 Oct;30(9):781-6. doi: 10.1055/s-0032-1333405. Epub 2013 Jan 28.
OBJECTIVE
To determine if supplemental perioperative oxygen will reduce surgical site infection (SSI) following cesarean delivery.
METHODS
This is a randomized, controlled trial evaluating SSI following either 30% or 80% fraction of inspired oxygen (FIO2) during and 2 hours after cesarean delivery. Anesthesia providers administered FIO2 via a high-flow oxygen blender. Subjects, surgeons, and wound evaluation teams were blinded. Serial wound evaluations were performed. Data were analyzed using logistic regression models, Fisher exact test, and t test.
RESULTS
In all, 179 women were randomized, and 160 subjects were included in the analysis. There were 12/83 (14.5%) SSIs in the control group versus 10/77 (13.0%) in the investigational group (p = 0.82). Caucasian race, increased body mass index, and longer operative time were identified as significant risk factors for infection (p = 0.026, odds ratio 0.283; p = 0.05, odds ratio = 1.058; p = 0.037, odds ratio = 1.038, respectively).
CONCLUSION
Perioperative oxygenation with 80% Fio2 is not effective in reducing SSI following cesarean delivery.
目的
确定剖宫产围手术期补充吸氧是否会降低手术部位感染（SSI）的发生率。
方法
这是一项随机对照试验，评估了剖宫产术中及术后 2 小时分别给予 30%和 80%吸入氧分数（FIO2）时的 SSI 发生率。麻醉提供者通过高流量氧气混合器给予 FIO2。对受试者、外科医生和伤口评估小组进行了盲法处理。进行了连续的伤口评估。使用逻辑回归模型、Fisher 确切检验和 t 检验进行数据分析。
结果
共有 179 名女性被随机分组，160 名受试者纳入分析。对照组有 12/83（14.5%）的感染病例，而实验组有 10/77（13.0%）（p = 0.82）。白种人种族、体重指数增加和手术时间延长被确定为感染的显著危险因素（p = 0.026，优势比 0.283；p = 0.05，优势比= 1.058；p = 0.037，优势比= 1.038）。
结论
剖宫产围手术期给予 80%Fio2 吸氧并不能降低 SSI 的发生率。
Zotero 插件