亚甲基四氢叶酸还原酶基因多态性与滤泡性淋巴瘤风险的关联：一项荟萃分析。
Methylenetetrahydrofolate reductase gene polymorphisms association with the risk of follicular lymphoma: a meta-analysis.
作者信息
Xu Jing-Yan, Sun Yun-Yu, Zhou Min, Wang Jing, Zhang Qi-Guo, Xu Xi-Hui, Zeng Hui, Ouyang Jian
机构信息
Department of Hematology, Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 321 Zhongshan Road, Nanjing, 210008, People's Republic of China.
出版信息
Tumour Biol. 2013 Jun;34(3):1467-71. doi: 10.1007/s13277-013-0670-x. Epub 2013 Jan 29.
To date, case-control studies on the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and follicular lymphoma have provided controversial results. To clarify the effect of MTHFR polymorphisms on the risk of follicular lymphoma, a meta-analysis of all case-control studies was performed. The fixed effects and random effects model showed that the C677T polymorphism was associated with a risk of follicular lymphoma among Caucasian populations, and A1298C polymorphism was associated with a risk of follicular lymphoma among Asian populations. Our pooled data suggest evidence for a major role of MTHFR polymorphisms in the carcinogenesis of follicular lymphoma.
迄今为止，关于亚甲基四氢叶酸还原酶（MTHFR）基因多态性与滤泡性淋巴瘤之间关联的病例对照研究结果存在争议。为了阐明MTHFR基因多态性对滤泡性淋巴瘤风险的影响，我们对所有病例对照研究进行了荟萃分析。固定效应模型和随机效应模型均显示，C677T多态性与白种人群中滤泡性淋巴瘤的风险相关，而A1298C多态性与亚洲人群中滤泡性淋巴瘤的风险相关。我们的汇总数据表明，MTHFR基因多态性在滤泡性淋巴瘤的致癌过程中起主要作用。
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