Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China ; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Chin J Cancer Res. 2012 Jun;24(2):90-6. doi: 10.1007/s11670-012-0090-2.
Lymph node status is a key prognostic factor in penile squamous cell carcinoma. Recently, growing evidence indicates a multimodality approach consisting of neoadjuvant chemotherapy followed by consolidation surgery improves the outcome of locally advanced penile cancer. Thus, accurate estimation of survival probability in node-positive penile cancer is critical for treatment decision making, counseling of patients and follow-up scheduling. This article reviewed evolving developments in assessing the risk for cancer progression based on lymph node related variables, such as the number of metastatic lymph nodes, bilateral lymph node metastases, the ratio of positive lymph nodes, extracapsular extension of metastatic lymph nodes, pelvic lymph node metastases, metastatic deposit in sentinel lymph nodes and N stage in TNM classification. Controversial issues surrounding the prognostic value of these nodal related predictors were also discussed.
淋巴结状态是阴茎鳞癌的一个关键预后因素。最近，越来越多的证据表明，新辅助化疗后行巩固性手术的多模态方法可改善局部晚期阴茎癌的预后。因此，准确评估淋巴结阳性阴茎癌的生存概率对于治疗决策、患者咨询和随访安排至关重要。本文综述了基于淋巴结相关变量评估癌症进展风险的新进展，如转移淋巴结数量、双侧淋巴结转移、阳性淋巴结比例、转移性淋巴结外侵、盆腔淋巴结转移、前哨淋巴结转移中的转移灶以及 TNM 分期中的 N 分期。还讨论了这些淋巴结相关预测因子的预后价值所存在的争议问题。
