吸入 A 组链球菌制剂气雾剂治疗肺癌的疗效。
The efficacy of the inhalation of an aerosolized Group A streptococcal preparation in the treatment of lung cancer.
机构信息
Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China; ; Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, China;
出版信息
Chin J Cancer Res. 2012 Dec;24(4):346-52. doi: 10.3978/j.issn.1000-9604.2012.10.08.
OBJECTIVE
To observe the efficacy of the inhalation of an aerosolized group A streptococcal (GAS) preparation in treating orthotopic lung cancer in mouse models and assess the feasibility, safety, and effectiveness of this administration mode for lung cancer.
METHODS
Lewis lung carcinoma (LLC) cell strains were administered via intrathoracic injection to establish orthotopic lung cancer mouse models. After the tumor-bearing models were successfully established, as confirmed by computed tomography, the mice were administered by inhalation with an aerosolized GAS preparation (GAS group) or aerosolized normal saline (control group). The anti-tumor effect of the aerosolized GAS preparation was evaluated histologically; meanwhile, the survival and quality of life were compared between these two groups.
RESULTS
The aerosolized GAS preparation showed remarkably anti-tumor effect, causing the necrosis of the orthotopic lung cancer cells in tumor-bearing mice. Furthermore, mice in the GAS group had significantly better quality of life and longer survival than those in control group.
CONCLUSIONS
The inhalation of aerosolized GAS preparation may be a feasible, safe and effective solution for lung cancer.
目的
观察雾化 A 组链球菌（GAS）制剂治疗原位肺癌小鼠模型的疗效，并评估该给药方式治疗肺癌的可行性、安全性和有效性。
方法
通过胸腔内注射建立Lewis 肺癌（LLC）细胞株原位肺癌小鼠模型。在通过计算机断层扫描确认肿瘤模型建立成功后，对小鼠进行雾化 GAS 制剂（GAS 组）或雾化生理盐水（对照组）吸入治疗。通过组织学评估雾化 GAS 制剂的抗肿瘤作用，同时比较两组之间的生存和生活质量。
结果
雾化 GAS 制剂显示出显著的抗肿瘤作用，导致荷瘤小鼠原位肺癌细胞坏死。此外，GAS 组的小鼠生活质量明显优于对照组，且生存期更长。
结论
雾化 GAS 制剂吸入可能是治疗肺癌的一种可行、安全且有效的方法。
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