Department of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
J Investig Med. 2013 Mar;61(3):551-7. doi: 10.2310/JIM.0b013e31828298ce.
Several large-scale clinical studies have consistently demonstrated that use of inhibitors of renin-angiotensin system such as angiotensin-converting enzyme inhibitors and angiotensin receptor blockers was associated with significant reduction of new-onset diabetes in patients with insulin resistance such as primary hypertension. Such observations stimulated major investigations into the interaction of angiotensin and insulin signaling systems, which in turn led to the discovery of a cross talk at several steps between the 2 pathways. Evidence from these clinical trials and from the experimental models of insulin resistance including our findings in ZSF rat and other animal models will be discussed in this review.
几项大规模的临床研究一致表明，使用肾素-血管紧张素系统抑制剂，如血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂，与患有胰岛素抵抗的患者（如原发性高血压）的新发糖尿病显著减少相关。这些观察结果激发了对血管紧张素和胰岛素信号系统相互作用的主要研究，这反过来又导致在这两个途径的几个步骤之间发现了交叉对话。来自这些临床试验和胰岛素抵抗的实验模型的证据，包括我们在 ZSF 大鼠和其他动物模型中的发现，将在本综述中进行讨论。
