Naughton Kelli Ann
Mount Sinai Medical Center, NY, USA.
Adv Neonatal Care. 2013 Feb;13(1):9-19; quiz 20-1. doi: 10.1097/ANC.0b013e31827ed9d3.
Many agents, both pharmacologic and nonpharmacologic, have been studied to alleviate neonatal pain, and the research is extensive. The 2 most commonly studied nonpharmacologic agents studied have been sucrose and nonnutritive sucking (NNS). There is increasing evidence that the synergistic effect of sucrose and NNS is more effective than the effect of sucrose or NNS alone. The purpose of this integrative review of the literature was to determine whether there is a relationship between the synergistic effect of combining sucrose and NNS administered before and during painful procedures, and reducing procedural pain in both preterm and term neonates. This integrative review indicates that the combination of sucrose and NNS is a safe, effective, and clinically significant means of providing procedural pain relief in neonates, both term and preterm.
为减轻新生儿疼痛，人们对许多药物和非药物制剂进行了研究，相关研究颇为广泛。研究最多的两种非药物制剂是蔗糖和非营养性吸吮（NNS）。越来越多的证据表明，蔗糖和NNS的协同作用比单独使用蔗糖或NNS的效果更显著。本文献综合综述的目的是确定在疼痛操作前及操作过程中联合使用蔗糖和NNS的协同作用与减轻足月儿和早产儿操作疼痛之间是否存在关联。该综合综述表明，蔗糖和NNS联合使用是为足月儿和早产儿提供操作疼痛缓解的一种安全、有效且具有临床意义的方法。
