Gautron M, Jazat F, Ratinahirana H, Hauw J J, Guilbaud G
Unité de Recherches de Physiopharmacologié du systeme nerveux, INSERM U 1610, Paris, France.
Neurosci Lett. 1990 Mar 26;111(1-2):28-33. doi: 10.1016/0304-3940(90)90339-b.
Morphology or peripheral myelinated fibres was analyzed in rats exhibiting hyperalgesia and allodynia with mechanical and thermal stimuli, consecutive to a mononeuropathy induced by 4 loose ligatures around a sciatic nerve. This preliminary study was based on weeks 2-3 after surgery, the time of the maximum alterations of the pain-related behaviour. At this time, contrasting with a marked decrease of the large afferent fibres a consistent number of much less than 5 micron fibres was pointed out. In addition to their extremely short internodal length, the majority of these fibres had an abnormal g-ratio, thus an abnormal myelin sheath. It is suggested that this group of abnormal fibres might be related to the A delta fibres described in neuromas and involved in pain-related behaviours seen in the mononeuropathic rats.
在通过对坐骨神经周围进行4次宽松结扎诱导单神经病后，对表现出机械和热刺激引起的痛觉过敏和异常性疼痛的大鼠的形态学或外周有髓纤维进行了分析。这项初步研究基于术后2至3周，即疼痛相关行为变化最大的时期。此时，与大的传入纤维明显减少形成对比的是，指出了数量一致且远少于5微米的纤维。除了其极短的节间长度外，这些纤维中的大多数具有异常的g比值，因此髓鞘异常。有人认为，这组异常纤维可能与神经瘤中描述的Aδ纤维有关，并参与单神经病大鼠中出现的疼痛相关行为。
