神经周围侵犯和/或脉管侵犯对早期口腔鳞状细胞癌患者生存的影响。
The impact of perineural invasion and/or lymphovascular invasion on the survival of early-stage oral squamous cell carcinoma patients.
机构信息
Department of Otolaryngology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
出版信息
Ann Surg Oncol. 2013 Jul;20(7):2388-95. doi: 10.1245/s10434-013-2870-4. Epub 2013 Jan 30.
BACKGROUND
For early-stage oral squamous cell carcinoma (OSCC) patients, the impact of perineural invasion (PNI) and lymphovascular invasion (LVI) on disease control and survival has not been clarified.
METHODS
The medical records of all early-stage OSCC patients who underwent curative surgery between 2004 and 2009 were reviewed.
RESULTS
A total of 442 early stage patients were included in this study. There were 360 patients in group A (without PNI or LVI) and 82 patients in group B (with PNI and/or LVI). Between groups A and B patients, there were no significant differences in the 5-year disease-free survival (73.8 vs 68.7 %, p = 0.48) and overall survival (90.9 vs 86.1 %, p = 0.25). Between groups A and B patients without postoperative radiotherapy (PORT), there were no significant differences in the 5-year disease-free survival (73.8 vs 70.2 %, p = 0.51) and overall survival (90.9 vs 85.2 %, p = 0.18). Between group B patients with and without PORT, there was no significant difference in either the disease-free survival (61.1 vs 70.2 %, p = 0.98) and overall survival (88.9 vs 85.2 %, p = 0.64). Multivariate analyses revealed that PNI, LVI, and PORT could not provide significant effect on treatment outcome.
CONCLUSIONS
PNI and LVI were not significant risk factors for the disease control and overall survival for early stage OSCC patients. Furthermore, PORT could not provide an additional benefit for the disease control and overall survival for stages I and II OSCC patients with PNI and/or LVI.
背景
对于早期口腔鳞状细胞癌（OSCC）患者，神经周围侵犯（PNI）和脉管侵犯（LVI）对疾病控制和生存的影响尚不清楚。
方法
回顾了 2004 年至 2009 年间接受根治性手术的所有早期 OSCC 患者的病历。
结果
本研究共纳入 442 例早期患者。A 组 360 例（无 PNI 或 LVI），B 组 82 例（有 PNI 和/或 LVI）。A 组和 B 组患者 5 年无病生存率（73.8%比 68.7%，p=0.48）和总生存率（90.9%比 86.1%，p=0.25）无显著差异。A 组和 B 组中未接受术后放疗（PORT）的患者 5 年无病生存率（73.8%比 70.2%，p=0.51）和总生存率（90.9%比 85.2%，p=0.18）无显著差异。B 组中有和无 PORT 的患者在无病生存率（61.1%比 70.2%，p=0.98）和总生存率（88.9%比 85.2%，p=0.64）方面也无显著差异。多因素分析显示，PNI、LVI 和 PORT 不能对治疗结果产生显著影响。
结论
PNI 和 LVI 不是早期 OSCC 患者疾病控制和总体生存率的显著危险因素。此外，对于有 PNI 和/或 LVI 的 I 期和 II 期 OSCC 患者，PORT 不能为疾病控制和总体生存率提供额外获益。
Zotero 插件