Han Sang Sook, Park Jee Eun, Kim Nam Eun, Kang Hwa Ja
College of Nursing Science/East-West Nursing Research Institute, Kyung Hee University, Seoul, Korea.
J Korean Acad Nurs. 2012 Dec;42(6):791-8. doi: 10.4040/jkan.2012.42.6.791.
The purpose of this study was to analyze the effectiveness of saline solution vs. heparinized-saline for maintenance of arterial lines and to detect changes in platelet and aPTT as physiological indexes.
In this nonequivalent control group, non-synchronized, double-blind study the effects of heparinized and saline solution on the maintenance of arterial lines were compared. Fifty five patients received the heparinized solution and fifty nine patients received the saline solution. All patients who had surgery in K-university hospital between September and December 2011 were eligible for participation in the study.
There was no statistically significant difference between the saline and the heparin group in the maintenance time of the arterial lines or the number of irrigations. There was no statistically significant difference between the groups in changes in the number of platelets and aPTT for interaction between the groups and time intervals.
The results indicate that saline solution can be used as an irrigation solution for the maintenance of arterial lines of adult surgical patients, rather than heparinized-saline, in view of potential risk factors in the use of heparin.
本研究旨在分析生理盐水与肝素盐水在维持动脉导管通畅方面的有效性，并检测血小板和活化部分凝血活酶时间（aPTT）作为生理指标的变化。
在这项非等效对照组、非同步、双盲研究中，比较了肝素盐水和生理盐水对维持动脉导管通畅的效果。55例患者接受肝素盐水，59例患者接受生理盐水。2011年9月至12月在K大学医院接受手术的所有患者均符合参与本研究的条件。
在动脉导管的维持时间或冲洗次数方面，生理盐水组和肝素组之间无统计学显著差异。在血小板数量变化和aPTT方面，两组之间在组间与时间间隔的交互作用上无统计学显著差异。
鉴于肝素使用中的潜在风险因素，结果表明生理盐水可作为成年外科手术患者维持动脉导管通畅的冲洗液，而非肝素盐水。
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