Whitta Rob K S, Hall Kelly F M, Bennetts Trish M, Welman Lorraine, Rawlins Peter
Palmerston North Hospital, Palmerston North, New Zealand.
Crit Care Resusc. 2006 Sep;8(3):205-8.
Heparin is used as a flush solution for intravenous and intra-arterial lines, but has a number of drug interactions, as well as potentially serious side effects.
We compared the function of arterial lines for both monitoring and blood sampling when flushed with either normal saline or saline containing heparin (1 unit/mL). Sixty-five patients were recruited at this mixed medical and surgical Level 2 intensive care unit. Patients were randomised to receive either normal saline (NS) or heparinised saline (HS) (3 mL/hour as a continuous flush). Each patient's nurse was asked to score the function of the line at the end of each nursing shift.
35 patients were recruited in the NS group and 30 in the HS group. Mean study duration was 5.8 and 6.6 days for the NS and HS groups, respectively. The scores for the intravascular line for each patient were summed, and the percentage of the total possible score was calculated. Mean percentage scores were 83% (NS group) and 82% (HS group). Comparison using the central limit theorem showed no difference between the groups at the 95% confidence interval (-6% to 10%).
Heparin as a continuous flush at 3 units/hour does not improve the function of arterial lines compared with a continuous normal-saline flush.
肝素被用作静脉和动脉管路的冲洗液，但存在多种药物相互作用以及潜在的严重副作用。
我们比较了用生理盐水或含肝素（1单位/毫升）的生理盐水冲洗时动脉管路在监测和采血方面的功能。在这个内科和外科混合的二级重症监护病房招募了65名患者。患者被随机分配接受生理盐水（NS）或肝素化生理盐水（HS）（以3毫升/小时持续冲洗）。要求每位患者的护士在每个护理班次结束时对管路功能进行评分。
NS组招募了35名患者，HS组招募了30名患者。NS组和HS组的平均研究持续时间分别为5.8天和6.6天。计算每位患者血管内管路的得分总和以及占总可能得分的百分比。平均百分比得分分别为83%（NS组）和82%（HS组）。使用中心极限定理进行比较显示，在95%置信区间（-6%至10%）内两组之间无差异。
与持续生理盐水冲洗相比，以3单位/小时持续冲洗肝素并不能改善动脉管路的功能。
