胰高血糖素样肽-1受体激活的环磷酸腺苷介导的多效性作用。聚焦于“艾塞那肽-4通过抑制内质网应激和激活肌浆网钙ATP酶2a减轻高糖诱导的心肌细胞凋亡” - Suppr

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超能文献

Cyclic AMP-mediated pleiotropic effects of glucagon-like peptide-1 receptor activation. Focus on "Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a".

作者信息

Ye Yumei, Birnbaum Yochai

出版信息

Am J Physiol Cell Physiol. 2013 Mar;304(6):C505-7. doi: 10.1152/ajpcell.00419.2012. Epub 2013 Jan 30.

DOI:10.1152/ajpcell.00419.2012

PMID:23364263

Abstract

摘要

相似文献

Cyclic AMP-mediated pleiotropic effects of glucagon-like peptide-1 receptor activation. Focus on "Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a".胰高血糖素样肽-1受体激活的环磷酸腺苷介导的多效性作用。聚焦于“艾塞那肽-4通过抑制内质网应激和激活肌浆网钙ATP酶2a减轻高糖诱导的心肌细胞凋亡”

Am J Physiol Cell Physiol. 2013 Mar;304(6):C505-7. doi: 10.1152/ajpcell.00419.2012. Epub 2013 Jan 30.

Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a.Exendin-4 通过抑制内质网应激和激活 SERCA2a 减轻高糖诱导的心肌细胞凋亡。

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Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism.艾塞那肽-4通过依赖SIRT1的机制减轻内质网应激。

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Exendin-4, a glucagon-like peptide-1 receptor agonist, inhibits cell apoptosis induced by lipotoxicity in pancreatic β-cell line.Exendin-4，一种胰高血糖素样肽-1 受体激动剂，可抑制脂毒性诱导的胰岛β细胞系细胞凋亡。

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Differential protective effects of exenatide, an agonist of GLP-1 receptor and Piragliatin, a glucokinase activator in beta cell response to streptozotocin-induced and endoplasmic reticulum stresses.Exenatide，一种 GLP-1 受体激动剂，和 Piragliatin，一种葡萄糖激酶激活剂，对链脲佐菌素诱导的和内质网应激的β细胞反应具有不同的保护作用。

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Role of ERp46 in β-cell lipoapoptosis through endoplasmic reticulum stress pathway as well as the protective effect of exendin-4.内质网蛋白 46 通过内质网应激通路在β细胞脂肪凋亡中的作用以及 exendin-4 的保护作用。

Biochem Biophys Res Commun. 2012 Sep 28;426(3):324-9. doi: 10.1016/j.bbrc.2012.08.072. Epub 2012 Aug 23.

Exendin-4 improves cardiac function in mice overexpressing monocyte chemoattractant protein-1 in cardiomyocytes.艾塞那肽-4可改善心肌细胞中单核细胞趋化蛋白-1过表达小鼠的心脏功能。

J Mol Cell Cardiol. 2014 Nov;76:172-6. doi: 10.1016/j.yjmcc.2014.08.022. Epub 2014 Sep 6.

Exendin-4 alleviates angiotensin II-induced senescence in vascular smooth muscle cells by inhibiting Rac1 activation via a cAMP/PKA-dependent pathway.艾塞那肽-4通过cAMP/PKA依赖性途径抑制Rac1激活，从而减轻血管紧张素II诱导的血管平滑肌细胞衰老。

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Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes.艾塞那肽（合成艾塞那肽-4）的药理学：改善2型糖尿病血糖控制的潜在疗法。

Regul Pept. 2004 Feb 15;117(2):77-88. doi: 10.1016/j.regpep.2003.10.028.

Inhibition of the expression of TGF-β1 and CTGF in human mesangial cells by exendin-4, a glucagon-like peptide-1 receptor agonist.胰高血糖素样肽-1受体激动剂艾塞那肽-4对人系膜细胞中转化生长因子-β1和结缔组织生长因子表达的抑制作用

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