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我们是否忽视了糖尿病性残疾:一项糖尿病性肌病的横断面研究。

Are we ignoring diabetic disability: a cross sectional study of diabetic myopathy.

作者信息

Shah Swati, Sonawane Pranali, Nahar Pradeep, Buge Kiran, Vaidya Savita

机构信息

Department of Physiology, B. J. Medical College, Pune, Maharashtra, India.

出版信息

Indian J Med Sci. 2011 May;65(5):186-92.

Abstract

BACKGROUND

The complications associated with type 2 Diabetes Mellitus (DM) may cause functional impairment in older people. Recently it has been proved that motor dysfunction in the form of skeletal muscle dysfunction does occur in type II DM. However very few studies have assessed the upper limb skeletal muscle dysfunction.

OBJECTIVES

The study was aimed to assess the hand grip strength, endurance in type 2 DM patients and compare the same with age matched healthy controls. We also correlated glycosylated Hb and duration of illness with the hand grip strength and endurance in the patients.

MATERIALS AND METHODS

Hand grip dynamometer was used to measure the hand grip strength and endurance in sixty diagnosed patients of type II DM. Similar tests were performed in age matched healthy controls. Blood samples were collected for blood glucose fasting, postprandial levels and Hb1AC in both the groups. Comparisons between patients and controls, and correlations were done by applying suitable tests.

RESULTS

The hand grip muscle strength and endurance in type II DM patients were significantly lower as compared to the normal controls (P < 0.05, P < 0.001). There was no correlation between the hand grip muscle strength and endurance with HbA1c and the duration of the disease in the patients of type II DM (P > 0.05).

CONCLUSIONS

The present study shows that type II DM patients suffer from skeletal muscle dysfunction in the form of reduced hand grip strength and endurance. Hence the treating Physician should not be ignorant about these disabilities. In addition to the strict measures to control the blood glucose levels, interventions to improve the muscle mass and strength in these patients should be undertaken.

摘要

背景

2型糖尿病(DM)相关并发症可能导致老年人功能障碍。最近已证实,II型糖尿病确实会出现以骨骼肌功能障碍形式存在的运动功能障碍。然而,很少有研究评估上肢骨骼肌功能障碍。

目的

本研究旨在评估2型糖尿病患者的握力、耐力,并与年龄匹配的健康对照组进行比较。我们还将糖化血红蛋白和病程与患者的握力和耐力进行了相关性分析。

材料与方法

使用握力计测量60例确诊的II型糖尿病患者的握力和耐力。在年龄匹配的健康对照组中进行类似测试。两组均采集血样检测空腹血糖、餐后血糖水平和糖化血红蛋白。通过应用合适的测试对患者和对照组进行比较,并进行相关性分析。

结果

与正常对照组相比,II型糖尿病患者的握力和耐力显著降低(P < 0.05,P < 0.001)。II型糖尿病患者的握力和耐力与糖化血红蛋白及病程之间无相关性(P > 0.05)。

结论

本研究表明,II型糖尿病患者存在以握力和耐力下降形式表现的骨骼肌功能障碍。因此,治疗医生不应忽视这些功能障碍。除了严格控制血糖水平的措施外,还应采取干预措施来改善这些患者的肌肉质量和力量。

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