Ozkaya Halit, Akcan Abdullah Barış, Aydemir Gökhan, Akbaş Mert
Department of Pediatrics, GATA Haydarpaşa Teaching Hospital, İstanbul, Turkey.
Agri. 2012;24(4):187-90. doi: 10.5505/agri.2012.68542.
Meperidine is an opiod analgesic used in a variety of clinical situations. The active metabolite, normeperidine, is a central nervous system excitatory agent and has the ability to cause irritability, hyperreflexia, tremor, myoclonus and seizures. Previously identified risk factors for the development of meperidine-related seizures include renal failure, high meperidine dosages, and co-adminestration of hepatic enzyme inducing medications or phenothiazines which decreases seizure treshold. Patients with normal renal function rarely manifest seizure activity when given meperidine. Here we report a 10 year old boy with a femur fraction who had normal renal function. We used low dose meperidine due to post operative pains.
