Gao Mingwu, Mukkamala Ramakrishna
Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:232-5. doi: 10.1109/EMBC.2012.6345912.
Pulse transit time (PTT) often shows strong correlation with blood pressure (BP) and may therefore represent a means for achieving continuous, non-invasive, and cuff-less BP monitoring. However, construction of the subject-specific curve needed to calibrate PTT to BP conventionally requires simultaneous measurements of PTT and BP during an experimental perturbation that varies BP over a significant range. We propose a technique for perturbationless calibration of PTT to BP. This technique constructs the calibration curve from central and peripheral BP waveforms by exploiting the natural pulsatile variation in the waveforms via a nonlinear tube-load model. We conducted initial testing of the technique in animals by applying it to the waveforms during a baseline period and then predicting mean BP during subsequent major hemodynamic interventions via PTT calibrated with the resulting curve. The bias in the mean BP error was 4.9 mmHg, while the precision in this error was 7.6 mmHg.
脉搏传输时间（PTT）通常与血压（BP）呈现出强相关性，因此可能代表了一种实现连续、无创且无需袖带的血压监测的方法。然而，传统上校准PTT与血压所需的个体特异性曲线构建，需要在实验性扰动期间同时测量PTT和血压，该扰动会在较大范围内改变血压。我们提出了一种用于PTT与血压无扰动校准的技术。该技术通过非线性管负载模型利用波形中的自然脉动变化，从中心和外周血压波形构建校准曲线。我们在动物身上对该技术进行了初步测试，将其应用于基线期的波形，然后通过用所得曲线校准的PTT预测随后主要血流动力学干预期间的平均血压。平均血压误差的偏差为4.9 mmHg，而该误差的精度为7.6 mmHg。
