Segmentation of urinary bladder in CT urography.

We are developing a Conjoint Level set Analysis and Segmentation System (CLASS) for bladder segmentation on CTU, which is a critical component for computer aided diagnosis of bladder cancer. A challenge for bladder segmentation is the presence of regions without contrast (NC) and filled with IV contrast (C). According to the characteristics of the bladder in CTU, CLASS is designed to perform number tasks such as preprocessing, initial segmentation, 3D and 2D level set segmentation and post-processing. CLASS segments separately the NC and the C regions of the bladder. In the post-processing stage the final contour is obtained based on the union of the NC and C contours. 70 bladders were segmented. Of the 70 bladders 31 contained lesions, 24 contained wall thickening, and 15 were normal. The performance of CLASS was assessed by rating the quality of the contours on a 5-point scale (1="very poor", 3="fair", 5="excellent"). The average quality ratings for the 12 completely no contrast (NC) and 5 completely contrast-filled (C) bladder contours were 3.3±1.0 and 3.4±0.5, respectively. The average quality ratings for the 53 NC and 53 C regions of the 53 partially contrast-filled bladders were 4.0±0.7 and 4.0±1.0, respectively. Quality ratings of 4 or above were given for 87% (46/53) NC and 77% (41/53) C regions. Only 4% (2/53) NC and 9% (5/53) C regions had ratings under 3. After combining the NC and C contours for each of the 70 bladders, 66% (46/70) had quality ratings of 4 or above. Only 6% (4/70) had ratings under 3. The average quality rating was 3.8±0.7. The results demonstrate the potential of CLASS for automated segmentation of the bladder.