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用于神经电极阵列的聚对二甲苯涂层金属轨道——利用不同激光系统的制造方法及改进

Parylene-coated metal tracks for neural electrode arrays - fabrication approaches and improvements utilizing different laser systems.

作者信息

Kohler Fabian, Schuettler Martin, Stieglitz Thomas

机构信息

Laboratory of Biomedical Microtechnology, Dept. of Microsystems Engineering – IMTEK, Univ. of Freiburg, Germany.

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:5130-3. doi: 10.1109/EMBC.2012.6347148.

Abstract

In the past we developed a method for the fabrication of neural electrodes based on laser-structuring metal foil to form tracks and electrode sites within a silicone rubber substrate. Here, this process was refined by an additional coating of the laser-patterned metal tracks to improve their mechanical properties. Parylene C has been found to be the coating material of choice due to excellent electrical and mechanical characteristics and its well known biocompatibility. An almost ten times increased tensile strength compared to uncoated tracks could be achieved. Investigating the electrical properties of parylene C and silicone rubber attested both materials excellent insulating capabilities by withstanding voltages of more than 400 V(DC) for layer thicknesses as intended to be used in electrode array fabrication (some 10 µm). This paper outlines the feasibility of the manufacturing process using a 1064 nm Nd:YAG laser in the nanosecond pulse regime. However, an improvement of the whole processing was demonstrated when a 355 nm Nd:YVO(4) laser in the picosecond regime is used. Benefits of this short pulse duration range from ablating materials independent of their optical properties to increased manufacturing speed and superior processing quality.

摘要

过去,我们开发了一种基于激光结构化金属箔在硅橡胶基板内形成轨道和电极位点来制造神经电极的方法。在此,通过对激光图案化金属轨道进行额外涂层来改进该工艺,以提高其机械性能。由于聚对二甲苯C具有优异的电气和机械特性以及其众所周知的生物相容性,已被发现是首选的涂层材料。与未涂层的轨道相比,拉伸强度可提高近十倍。对聚对二甲苯C和硅橡胶的电学性能进行研究表明,对于电极阵列制造中预期使用的层厚度(约10微米),这两种材料在承受超过400 V(直流)的电压时均具有出色的绝缘能力。本文概述了在纳秒脉冲模式下使用1064 nm Nd:YAG激光制造工艺的可行性。然而,当使用皮秒模式下的355 nm Nd:YVO₄激光时,整个工艺得到了改进。这种短脉冲持续时间的优点包括能够独立于材料的光学特性进行烧蚀、提高制造速度以及获得卓越的加工质量。

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