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用于神经植入物的改进型聚酰亚胺薄膜电极。

Improved polyimide thin-film electrodes for neural implants.

作者信息

Ordonez Juan S, Boehler Christian, Schuettler Martin, Stieglitz Thomas

机构信息

Laboratory for Biomedical Microtechnology, Dept. of Microsystems Engineering - IMTEK, Univ. of Freiburg, Germany.

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:5134-7. doi: 10.1109/EMBC.2012.6347149.

Abstract

Thin-film electrode arrays for neural implants are necessary when large integration densities of stimulating or recording channels are required. However, delamination of the metallic layers from the polymer substrate leads to early failure of the device. Based on new adhesion studies of polyimide to SiC and diamond-like carbon (DLC) the authors successfully fabricated a 232-channel electrode array for retinal stimulation with improved adhesion. Layers of SiC and DLC were integrated into the fabrication procedure of polyimide-platinum (Pt) arrays to create fully coated metal wires, which adhere to the polyimide substrate even after 1 year of accelerated aging in saline solution. Studies on the inter-diffusion of Pt and SiC were conducted to establish an optimal thickness for a gold core of the platinum tracks, which is used for reducing the electrical track resistance. Furthermore, the electrochemical behaviour of the stimulating contacts coated with IrOx were studied in a long-term pulse tests over millions of pulses showing no deterioration of the coating.

摘要

当需要大量刺激或记录通道的集成密度时,用于神经植入的薄膜电极阵列是必不可少的。然而,金属层与聚合物基底的分层会导致器件过早失效。基于对聚酰亚胺与碳化硅和类金刚石碳(DLC)的新粘附研究,作者成功制造了一种用于视网膜刺激的232通道电极阵列,其粘附性得到了改善。碳化硅和类金刚石碳层被集成到聚酰亚胺 - 铂(Pt)阵列的制造过程中,以形成完全包覆的金属线,即使在盐溶液中加速老化1年后,这些金属线仍能粘附在聚酰亚胺基底上。对铂和碳化硅的相互扩散进行了研究,以确定铂迹线金芯的最佳厚度,该金芯用于降低电迹线电阻。此外,在数百万次脉冲的长期脉冲测试中研究了涂覆有氧化铱的刺激触点的电化学行为,结果表明涂层没有劣化。

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