Snityns'kyĭ V V
Ukr Biokhim Zh (1978). 1990 Jan-Feb;62(1):55-9.
Metabolism of carbohydrates in the brain of 110-day-feti, newborns (before taking the colostrum), 1-day-old and 5-day-old piglets, grown under sows or starved for 24 hours has been studied. Examination of brain slices with the use of 1-14C glucose and 6-14C glucose and determination of the glycolysis-limiting enzymes activity have shown that glycolysis is the main pathway of glucose utilization in the central nervous system of pigs during the transition from prenatal to postnatal development. The major portion of NADPH in the brain of new born piglets is supplied by dehydrogenases of the pentose-phosphate pathway. The increased activities of NADP-dependent malate and citrate dehydrogenases are found in the cytoplasm of astrocytes during the neonatal period. The decreased intensity of glycolysis and pentose-phosphate pathway in the brain of 1-day-old piglets is associated with the increased rate of malate and isocitrate oxidation. Starvation for 24 hours causes changes in the carbohydrate metabolism rates in the brain of piglets. The pentose-phosphate pathway rate increases by 70-80 per cent in the brain structures of piglets of the both groups. Besides, the iso-CDG activity also rises in the brain of 5-day-old animals. The high level of oxidation-reduction processes in the brain of older piglets at active glycolysis is supposed to be one of the peculiarities of energy metabolism in the central nervous system of animals which are resistant to starvation.
对在母猪哺育下或饥饿24小时的110天龄胎儿、新生儿（未摄取初乳前）、1日龄和5日龄仔猪大脑中的碳水化合物代谢进行了研究。使用1-14C葡萄糖和6-14C葡萄糖对脑切片进行检查并测定糖酵解限速酶活性，结果表明，在从产前到产后发育的过渡阶段，糖酵解是猪中枢神经系统中葡萄糖利用的主要途径。新生仔猪大脑中大部分NADPH由磷酸戊糖途径的脱氢酶提供。在新生儿期，星形胶质细胞胞质中NADP依赖性苹果酸脱氢酶和柠檬酸脱氢酶的活性增加。1日龄仔猪大脑中糖酵解和磷酸戊糖途径强度的降低与苹果酸和异柠檬酸氧化速率的增加有关。饥饿24小时会导致仔猪大脑中碳水化合物代谢速率发生变化。两组仔猪大脑结构中磷酸戊糖途径速率增加70-80%。此外，5日龄动物大脑中异柠檬酸脱氢酶（iso-CDG）活性也升高。活跃糖酵解时大龄仔猪大脑中高水平的氧化还原过程被认为是动物中枢神经系统能量代谢的特点之一，这些动物对饥饿具有抵抗力。
