Amano Akira, Kawabata Masanari, Yamashita Yoshiharu, Rusty Punzalan Florencio, Shimayoshi Takao, Kuwabara Hiroaki, Kunieda Yoshitoshi
Institute of Medical Engineering, University of Luebeck, 23562 Luebeck, Germany.
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:6624-7. doi: 10.1109/EMBC.2012.6347513.
To cope with the complexity of the biological function simulation models, model representation with description language is becoming popular. However, simulation software itself becomes complex in these environment, thus, it is difficult to modify the simulation conditions, target computation resources or calculation methods. In the complex biological function simulation software, there are 1) model equations, 2) boundary conditions and 3) calculation schemes. Use of description model file is useful for first point and partly second point, however, third point is difficult to handle for various calculation schemes which is required for simulation models constructed from two or more elementary models. We introduce a simulation software generation system which use description language based description of coupling calculation scheme together with cell model description file. By using this software, we can easily generate biological simulation code with variety of coupling calculation schemes. To show the efficiency of our system, example of coupling calculation scheme with three elementary models are shown.
为了应对生物功能模拟模型的复杂性,使用描述语言进行模型表示正变得越来越流行。然而,在这些环境中模拟软件本身变得复杂,因此,难以修改模拟条件、目标计算资源或计算方法。在复杂的生物功能模拟软件中,存在1)模型方程、2)边界条件和3)计算方案。描述模型文件的使用对于第一点和部分第二点是有用的,然而,对于由两个或更多基本模型构建的模拟模型所需的各种计算方案,第三点很难处理。我们引入了一个模拟软件生成系统,该系统使用基于描述语言的耦合计算方案描述以及细胞模型描述文件。通过使用该软件,我们可以轻松生成具有各种耦合计算方案的生物模拟代码。为了展示我们系统的效率,给出了具有三个基本模型的耦合计算方案示例。