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一种个性化二尖瓣关闭模拟器。

A personalized mitral valve closure simulator.

作者信息

Burlina P, Mukherjee R, Sprouse C

机构信息

Johns Hopkins University Applied Physics Laboratory, Laurel, MD 20723, USA.

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:6636-40. doi: 10.1109/EMBC.2012.6347516.

Abstract

We describe a method for performing modeling and simulation to predict the closure of the Mitral Valve (MV) using patient specific anatomical information derived from 3D Transesophageal Echocardiography (3D TEE). The ability to predict the MV closure behavior is an important step along the way of developing personalized simulation tools that would allow a surgeon to perform preoperative planning and decide between various MV repair options. While the MV is an important use case because of its relevance and prevalence among reconstructive cardiac interventions, the study described here can provide a blueprint to perform pre-operative planning for other cardiac surgical interventions. The method reported here exploits the Saint Venant-Kirchhoff elasticity model that is tuned to match empirical observations of the MV strainstress behavior. Using intraoperative 3D TEE data, the proposed simulator was evaluated over 10 test cases and resulted in mean prediction absolute error values of 1.81 mm.

摘要

我们描述了一种使用从三维经食管超声心动图(3D TEE)获得的患者特定解剖信息来进行建模和模拟,以预测二尖瓣(MV)关闭情况的方法。预测MV关闭行为的能力是开发个性化模拟工具过程中的重要一步,这种工具将使外科医生能够进行术前规划,并在各种MV修复方案之间做出决策。虽然由于MV在心脏重建干预中的相关性和普遍性,它是一个重要的应用案例,但此处描述的研究可以为其他心脏手术干预的术前规划提供蓝图。这里报告的方法利用了圣维南-柯西弹性模型,该模型经过调整以匹配MV应变-应力行为的经验观察结果。使用术中3D TEE数据,在所提出的模拟器上对10个测试案例进行了评估,平均预测绝对误差值为1.81毫米。

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