Mádle A, Kudová J, Vainer J, Smíd J
I. interní klinika lékarské fakulty UK, Plzen.
Vnitr Lek. 1990 Feb;36(2):128-33.
Using invasive electrophysiological methods, the authors evaluated the preparation Diltiazem VUFB tablets on parametres of sinus automaticity in the "sick sinus syndrome" and on properties of the atria. They confirmed significant inhibition of automaticity which is not signalized by a corresponding decrease of the nodal frequency, and may remain concealed and lead unexpectedly to disorders of the cardiac rhythm. This is not a specific property of the preparation, a similar action on the sick sinus is exerted by all calcium antagonists with clinically confirmed effects on the conduction system. Diltiazem is already produced in this country and sold on the market with the name of Discordin SPOFA tablets.
作者采用侵入性电生理方法，评估了地尔硫䓬VUFB片对“病态窦房结综合征”中窦房结自律性参数及心房特性的影响。他们证实了该药物对自律性有显著抑制作用，这种抑制作用并未通过结性频率的相应降低表现出来，可能会隐匿存在，并意外导致心律失常。这并非该制剂的特异性作用，所有已证实对传导系统有临床作用的钙拮抗剂对病态窦房结均有类似作用。地尔硫䓬在该国已生产，并以Discordin SPOFA片的名称在市场上销售。
