Department of Applied Chemistry and Biochemical Engineering, Faculty of Engineering, Shizuoka University, 3-5-1 Johoku Naka-ku, Hamamatsu 432-8561, Japan.
J Chromatogr A. 2013 Mar 1;1279:92-7. doi: 10.1016/j.chroma.2013.01.019. Epub 2013 Jan 10.
The diffusion coefficients D(12) of phenylbutazone at infinite dilution in supercritical CO(2) were measured by the chromatographic impulse response (CIR) method. The measurements were carried out over the temperature range from 308.2 to 343.2 K at pressures up to 40.0 MPa. In addition, the D(12) data of phenylbutazone at infinite dilution in ethanol were also measured by the Taylor dispersion method at 298.2-333.2K and at atmospheric pressure. The D(12) value of phenylbutazone increased from 4.45×10(-10) m(2) s(-1) at 298.2 K and 0.1 MPa in ethanol to about 1.43×10(-8) m(2) s(-1) at 343.2 K and 14.0 MPa in supercritical CO(2). It was found that all diffusion data of phenylbutazone measured in this study in supercritical CO(2) and in ethanol can be satisfactorily represented by the hydrodynamic equation over a wide range of fluid viscosity from supercritical state to liquid state with average absolute relative deviation of 5.4% for 112 data points.
在超临界 CO2 中无限稀释的苯丁唑酮的扩散系数 D(12)通过色谱脉冲响应 (CIR) 法测量。在 308.2 至 343.2 K 的温度范围内，在高达 40.0 MPa 的压力下进行了测量。此外，还通过泰勒分散法在 298.2-333.2 K 和大气压下测量了苯丁唑酮在无限稀释的乙醇中的 D(12)数据。苯丁唑酮的 D(12)值从 298.2 K 和 0.1 MPa 时的乙醇中的 4.45×10(-10) m2 s(-1)增加到 343.2 K 和 14.0 MPa 时的超临界 CO2 中的约 1.43×10(-8) m2 s(-1)。结果表明，在本研究中在超临界 CO2 和乙醇中测量的所有苯丁唑酮的扩散数据都可以通过流体粘度从超临界状态到液体状态的广泛范围内的流体力学方程很好地表示，112 个数据点的平均绝对相对偏差为 5.4%。
