Divisions of *General Internal Medicine †Infectious Diseases, Department of Medicine, School of Medicine, University of Colorado, CO ‡Department of Epidemiology, Children's Hospital Colorado, Aurora.
Clin J Pain. 2013 Nov;29(11):957-61. doi: 10.1097/AJP.0b013e31827c7b05.
Epidemiologic studies in the non-human immunodeficiency virus (HIV) positive population have shown greater health care utilization among persons with chronic non-cancer pain on opioid therapy. However, we are not aware of any similar data in the HIV positive population.
We evaluated health care utilization, as measured by emergency room (ER) visits and hospitalizations, among persons with HIV and chronic pain seen at an academic medical center, during the calendar year 2005. We compared these outcomes between patients on chronic opioid therapy with those not on opioids.
In univariate models chronic opioid therapy was associated with both ER visits and hospitalization: ER visits odds ratio (OR)=2.18 (95% confidence interval [CI], 1.30-3.66), hospitalization OR=1.90 (95% CI, 1.03-3.51). After multivariate analyses only nonsignificant trends remain: ER visits OR=1.71 (95% CI, 0.95-3.08); hospitalization OR=1.28 (95% CI, 0.66-2.49).
In our study HIV positive individuals with chronic pain were more likely to be seen in the ER and be hospitalized if they were on opioids. However, after controlling for other variables, the association with opioids no longer remained significant.
在非人类免疫缺陷病毒(HIV)阳性人群中进行的流行病学研究表明,慢性非癌症疼痛患者在接受阿片类药物治疗时,对医疗保健的利用度更高。然而,我们并不了解 HIV 阳性人群中是否存在类似的数据。
我们评估了在学术医疗中心就诊的 HIV 阳性慢性疼痛患者的医疗保健利用度,以急诊室(ER)就诊和住院次数来衡量。我们比较了接受慢性阿片类药物治疗的患者与未接受阿片类药物治疗的患者的这些结果。
在单变量模型中,慢性阿片类药物治疗与 ER 就诊和住院相关:ER 就诊的比值比(OR)=2.18(95%置信区间[CI],1.30-3.66),住院的 OR=1.90(95% CI,1.03-3.51)。经过多变量分析后,只有非显著趋势仍然存在:ER 就诊的 OR=1.71(95% CI,0.95-3.08);住院的 OR=1.28(95% CI,0.66-2.49)。
在我们的研究中,患有慢性疼痛的 HIV 阳性个体如果使用阿片类药物,更有可能去急诊室就诊和住院。然而,在控制其他变量后,与阿片类药物的关联不再具有统计学意义。