Paris Descartes University, Paris, France.
Eur J Clin Microbiol Infect Dis. 2013 Jun;32(6):729-34. doi: 10.1007/s10096-013-1815-y. Epub 2013 Feb 1.
Pyomyositis is a primary purulent infection of skeletal muscles mostly described in tropical areas. Staphylococcus aureus is by far the main causative microorganisms. In temperate areas, pyomyositis more frequently affects male adults with immunodeficiency. Gram-negative bacilli pyomyositis are uncommon and occur mainly in this context of immunodeficiency. Only one case of Enterobacter cloacae pyomyositis has been reported so far. Chronic Granulomatous Disease (CGD) is a rare inherited immunodeficiency characterized by a loss of NADPH oxidase activity in phagocytic cells that favors infections due to catalase-positive microorganisms. Pyomyositis has only been described once as a complication of CGD. We report here a case of Enterobacter cloacae-associated pyomyositis of the left thigh in a patient with CGD, and review the literature on Gram-negative pyomyositis.
肌脓肿是一种主要发生在热带地区的骨骼肌原发性化脓性感染。金黄色葡萄球菌是迄今为止主要的致病微生物。在温带地区，肌脓肿更常影响免疫功能低下的成年男性。革兰氏阴性杆菌性肌脓肿较为少见，主要发生在这种免疫功能低下的情况下。到目前为止，只有一例阴沟肠杆菌性肌脓肿的报告。慢性肉芽肿病（CGD）是一种罕见的遗传性免疫缺陷病，其特征是吞噬细胞中 NADPH 氧化酶活性丧失，有利于过氧化氢酶阳性微生物引起的感染。CGD 患者曾有一次肌脓肿作为并发症的报道。我们在此报告一例 CGD 患者左大腿阴沟肠杆菌相关性肌脓肿，并复习关于革兰氏阴性菌肌脓肿的文献。
