Ranganathan Kavitha, Wong Victor W, Krebsbach Paul H, Wang Stewart C, Cederna Paul S, Levi Benjamin
Department of Surgery, Section of Plastic Surgery, University of Michigan, Ann Arbor, MI, USA.
J Burn Care Res. 2013 Mar-Apr;34(2):219-26. doi: 10.1097/BCR.0b013e318280e2dd.
The use of fat grafting as a treatment for radiation and thermal injury is a recent application of a historically well-described operation. The autologous transplantation of fat has been used to treat reconstructive and cosmetic concerns for the past century. In those suffering from tissue fibrosis, contractures, and deformity, the importance of fat grafting is exaggerated because of the relative paucity of alternative solutions. Adipocytes recently have been popularized for their ability to regenerate and transform. Although large-scale randomized studies have not been performed to examine the effects of autologous fat transfer in patients suffering from thermal injury and tissue damage, smaller in vivo and in vitro studies have demonstrated reliable and reproducible improvements in tissue quality after fat grafting has been performed. The goal of this review of fat grafting in thermal injury is to describe the development of this technique from its historical roots to its current state using in vivo and in vitro models, to delineate the clinical indications for use, to describe variations in techniques, and to shed light on future applications of this seemingly simple, yet multifaceted management strategy.
将脂肪移植用作治疗放射性和热损伤的方法是一种历史悠久且描述详尽的手术的近期应用。在过去的一个世纪里，自体脂肪移植一直被用于治疗重建和美容方面的问题。在那些患有组织纤维化、挛缩和畸形的患者中，由于可供选择的解决方案相对较少，脂肪移植的重要性被进一步凸显。脂肪细胞近来因其再生和转化能力而受到广泛关注。尽管尚未进行大规模随机研究来检验自体脂肪移植对热损伤和组织损伤患者的影响，但规模较小的体内和体外研究已表明，进行脂肪移植后，组织质量有可靠且可重复的改善。这篇关于脂肪移植治疗热损伤的综述的目的是，利用体内和体外模型描述该技术从其历史根源到当前状态的发展过程，阐述其临床应用指征，描述技术差异，并阐明这种看似简单却多方面的治疗策略的未来应用前景。
