School of Biomedical Engineering, Southern Medical University, Guangzhou, China.
J Magn Reson Imaging. 2013 Sep;38(3):588-93. doi: 10.1002/jmri.24010. Epub 2013 Jan 31.
To compare myocardial T1 against T2 and T2* in patients with thalassemia major (TM) for myocardial iron characterization.
A total of 106 TM patients (29 ± 10 years; 58 males) were studied on a 1.5 Tesla scanner using dedicated T1, T2*, and T2 relaxometry sequences. A single mid-ventricular short axis slice was acquired within a breath-hold.
In patients with myocardial iron overload (T2* < 20 ms; n = 52), there were linear correlations between T2 and T2* (r = 0.82; P = 0.0), and between T1 and T2* (r = 0.83; P = 0.0). In patients with no myocardial iron (n = 54), T2* values were scattered with no significant correlation against T2 or T1. For all patients (n = 106) there was a strong linear correlation (r = 0.93; P = 0.0) between myocardial T1 and T2.
In patients with iron overload, myocardial T2 and T1 are correlated with T2*. In patients with low or normal myocardial iron concentration, other factors become dominant in affecting T2* values as shown by scattered T2* data. Myocardial T1 correlates linearly with T2 measurements in all patients suggesting that these two relaxation parameters avoid extrinsic magnetic field inhomogeneity effects and may potentially provide improved myocardial tissue characterization.
比较铁过载与铁正常患者心肌 T1 与 T2、T2*值，以对心肌铁含量进行特征分析。
在 1.5T 扫描仪上，使用专门的 T1、T2*和 T2 弛豫率序列，对 106 例重型地中海贫血（TM）患者（29 ± 10 岁；58 名男性）进行研究。屏气状态下采集一个心尖短轴中间层。
在心肌铁过载（T2* < 20ms；n=52）患者中，T2 与 T2*（r=0.82；P=0.0），T1 与 T2*（r=0.83；P=0.0）之间存在线性关系。在无心肌铁沉积患者（n=54）中，T2*值散布，与 T2 或 T1 无显著相关性。对于所有患者（n=106），心肌 T1 与 T2 之间存在很强的线性关系（r=0.93；P=0.0）。
在铁过载患者中，心肌 T2 和 T1 与 T2相关。在低或正常心肌铁浓度患者中，T2数据散布表明其他因素在影响 T2*值方面占据主导地位。所有患者的心肌 T1 与 T2 呈线性相关，提示这两个弛豫参数可避免外磁场不均匀性的影响，可能为心肌组织特征分析提供更好的方法。
