Walker D
Department of Physiology, Monash University, Clayton, Melbourne, Victoria.
Am J Physiol. 1990 May;258(5 Pt 2):R1213-6. doi: 10.1152/ajpregu.1990.258.5.R1213.
The effects of inhibiting prostaglandin (PG) synthesis on fetal breathing movements and on the amplitude of reflex contraction of the digastric muscle (five trials) or hindlimb semitendinosus muscle (seven trials) has been studied in six fetal lambs at 123-139 days gestation. Infusion of either indomethacin (100 mg) or acetaminophen (300 mg) in 30 ml saline over 30 min resulted in an increase in the amplitude and incidence of breathing movements for 3-18 h in the different trials, but there was no change in the mean amplitude of either reflex or in the normal variation of reflex amplitude with changes in electrocortical activity. It is concluded that PGs modulate fetal breathing movements by an action on the brain stem chemoreceptors but do not alter the excitability of neural pathways subserving some cranial and spinal reflexes.
在妊娠123 - 139天的6只胎羊中，研究了抑制前列腺素（PG）合成对胎儿呼吸运动以及对二腹肌（5次试验）或后肢半腱肌（7次试验）反射收缩幅度的影响。在不同试验中，于30分钟内将吲哚美辛（100毫克）或对乙酰氨基酚（300毫克）溶于30毫升生理盐水中输注，导致呼吸运动的幅度和发生率在3 - 18小时内增加，但反射的平均幅度或反射幅度随脑电活动变化的正常波动均无改变。得出的结论是，PGs通过作用于脑干化学感受器来调节胎儿呼吸运动，但不会改变维持某些颅神经和脊髓反射的神经通路的兴奋性。
