School of Psychology, University of Western Australia, Perth, Australia.
Sleep. 2013 Feb 1;36(2):203-20. doi: 10.5665/sleep.2374.
To examine episodic memory performance in individuals with obstructive sleep apnea (OSA).
Meta-analysis was used to synthesize results from individual studies examining the impact of OSA on episodic memory performance. The performance of individuals with OSA was compared to healthy controls or normative data.
Forty-two studies were included, comprising 2,294 adults with untreated OSA and 1,364 healthy controls. Studies that recorded information about participants at baseline prior to treatment interventions were included in the analysis.
PARTICIPANTS WERE ASSESSED WITH TASKS THAT INCLUDED A MEASURE OF EPISODIC MEMORY: immediate recall, delayed recall, learning, and/or recognition memory.
The results of the meta-analyses provide evidence that individuals with OSA are significantly impaired when compared to healthy controls on verbal episodic memory (immediate recall, delayed recall, learning, and recognition) and visuo-spatial episodic memory (immediate and delayed recall), but not visual immediate recall or visuo-spatial learning. When patients were compared to norms, negative effects of OSA were found only in verbal immediate and delayed recall.
This meta-analysis contributes to understanding of the nature of episodic memory deficits in individuals with OSA. Impairments to episodic memory are likely to affect the daily functioning of individuals with OSA.
考察阻塞性睡眠呼吸暂停（OSA）患者的情景记忆表现。
采用荟萃分析综合考察 OSA 对情景记忆表现影响的个体研究结果。将 OSA 患者的表现与健康对照者或常模数据进行比较。
纳入 42 项研究，共纳入 2294 例未经治疗的 OSA 成年患者和 1364 例健康对照者。纳入分析的研究记录了治疗干预前基线时参与者的信息。
采用包括情景记忆（即时回忆、延迟回忆、学习和/或识别记忆）在内的任务评估参与者。
荟萃分析的结果表明，与健康对照组相比，OSA 患者在言语情景记忆（即时回忆、延迟回忆、学习和识别）和视空间情景记忆（即时和延迟回忆）方面存在显著障碍，但在视觉即时回忆或视空间学习方面没有障碍。当将患者与常模进行比较时，仅在言语即时和延迟回忆中发现 OSA 的负面影响。
本荟萃分析有助于理解 OSA 患者情景记忆缺陷的性质。情景记忆障碍可能会影响 OSA 患者的日常功能。
