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本文引用的文献

1
Inducible nitric oxide synthetase genotype and Helicobacter pylori infection affect gastric cancer risk.诱导型一氧化氮合酶基因型和幽门螺杆菌感染影响胃癌风险。
World J Gastroenterol. 2012 Sep 21;18(35):4917-24. doi: 10.3748/wjg.v18.i35.4917.
2
A novel genetic polymorphism of inducible nitric oxide synthase is associated with an increased risk of gastric cancer.诱导型一氧化氮合酶的一种新型基因多态性与胃癌风险增加有关。
World J Gastroenterol. 2004 Nov 15;10(22):3278-83. doi: 10.3748/wjg.v10.i22.3278.
3
[Study on the Relationship between susceptibility of stomach neoplasm cancer and polymorphism of inducible nitric oxide synthase gene].[胃癌易感性与诱导型一氧化氮合酶基因多态性的关系研究]
Zhonghua Liu Xing Bing Xue Za Zhi. 2002 Oct;23(5):374-7.
4
Molecular cloning and structural organization of the human inducible nitric oxide synthase gene (NOS2).人类诱导型一氧化氮合酶基因（NOS2）的分子克隆与结构组织
Biochem Biophys Res Commun. 1996 Feb 27;219(3):784-8. doi: 10.1006/bbrc.1996.0311.

诱导型一氧化氮合酶基因型与幽门螺杆菌感染胃癌风险的关联可能归因于引物设计不当。

Association of inducible nitric oxide synthetase genotype and Helicobacter pylori infection gastric cancer risk may be due to faulty primer design.

出版信息

World J Gastroenterol. 2013 Jan 21;19(3):429-30. doi: 10.3748/wjg.v19.i3.429.

DOI:10.3748/wjg.v19.i3.429
PMID:23372371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3554833/
Abstract

Rafiei et al recently described an association between the presence of the C150T polymorphism of the inducible nitric oxide synthase (iNOS) gene and Helicobacter pylori (H. pylori) induced gastric cancer. When we used primer-BLAST to find the polymerase chain reaction (PCR) product that would be generated by the primers used by these authors no products against any of the sequences present in the GenBank database were found. Further analysis of the iNOS sequences present in the GenBank suggest that the result from their study might come from a faulty primer design and may thus represent an artifact. Alternatively they may be correct and have identified a truly interesting explanation for the mechanism whereby H. pylori induces gastric cancer but some additional experiments would be in order to exclude the possibility of a PCR artifact.

摘要

拉菲等人最近描述了诱导型一氧化氮合酶（iNOS）基因的 C150T 多态性与幽门螺杆菌（H. pylori）诱导胃癌之间的关联。当我们使用引物-BLAST 寻找这些作者使用的引物产生的聚合酶链反应（PCR）产物时，没有发现针对 GenBank 数据库中存在的任何序列的产物。对 GenBank 中存在的 iNOS 序列的进一步分析表明，他们的研究结果可能来自于错误的引物设计，因此可能代表一种假象。或者他们是正确的，并且已经为 H. pylori 诱导胃癌的机制找到了一个真正有趣的解释，但需要进行一些额外的实验来排除 PCR 假象的可能性。