Javalkar Vijayakumar, Banerjee Anirban Deep, Nanda Anil
Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
J Neurol Surg B Skull Base. 2012 Feb;73(1):1-10. doi: 10.1055/s-0032-1304835.
This study evaluated the outcomes, complications, and recurrence rates of posterior cranial fossa meningiomas. We retrospectively reviewed our surgical experience with 64 posterior cranial fossa meningiomas. Mean age was 56 years with a female preponderance (67.2%). Headache was the most common symptom. Retrosigmoid approach was the commonest surgical procedure (23.4%). The incidence of cranial nerve related complications was 28%. Postoperatively facial nerve weakness was observed in 11%. The incidence of cerebrospinal fluid leak was 4.6%. Gross total resection was achieved in 37 patients (58%). Sixteen patients (25%) with residual tumors underwent Gamma knife radiosurgery. Recurrence or tumor progression was observed in 12 patients (18.7%). Operative mortality was 3.1%. At their last follow-up, 93% of the cases achieved Glasgow Outcome Scale scores 4 or 5. Total excision is the ideal goal which can be achieved with meningiomas located in certain location, such as lateral convexity, but for other posterior fossa meningiomas the close proximity of critical structures is a major obstacle in achieving this goal. In practicality, a balance between good functional outcome and extent of resection is important for posterior cranial fossa meningiomas in proximity to critical structures.
本研究评估了后颅窝脑膜瘤的治疗结果、并发症及复发率。我们回顾性分析了64例后颅窝脑膜瘤的手术经验。平均年龄为56岁,女性占优势(67.2%)。头痛是最常见的症状。乙状窦后入路是最常用的手术方式(23.4%)。颅神经相关并发症的发生率为28%。术后观察到11%的患者出现面神经麻痹。脑脊液漏的发生率为4.6%。37例患者(58%)实现了肿瘤全切除。16例(25%)有残留肿瘤的患者接受了伽玛刀放射治疗。12例患者(18.7%)出现复发或肿瘤进展。手术死亡率为3.1%。在最后一次随访时,93%的病例格拉斯哥预后评分达到4分或5分。肿瘤全切除是理想目标,对于位于某些部位(如外侧凸面)的脑膜瘤可以实现,但对于其他后颅窝脑膜瘤,关键结构距离过近是实现这一目标的主要障碍。实际上,对于靠近关键结构的后颅窝脑膜瘤,在良好的功能预后和切除范围之间取得平衡很重要。