Heart Failure and Transplant Unit, Failure and Transplant Unit, St. Vincent’s Hospital, Victoria St., Darlinghurst, Sydney, NSW 2010, Australia.
Artif Organs. 2013 Mar;37(3):313-8. doi: 10.1111/j.1525-1594.2012.01567.x. Epub 2013 Feb 4.
The current recommended anticoagulation regimen during continuous flow centrifugal left ventricular device support is a combination of antiplatelet therapy as well as oral anticoagulation. Despite this, pump thrombosis occurs in rare situations. We report the risk factors and nonsurgical management and outcomes of five patients implanted with continuous flow centrifugal left ventricular assist devices who displayed clinical, hemodynamic, and laboratory features of intrapump thrombosis. This information may support the use of intravenous thrombolytics for suspected pump thrombus in these newer generation devices.
目前，在连续流动离心式左心室辅助装置支持期间，建议的抗凝方案是抗血小板治疗与口服抗凝相结合。尽管如此，在极少数情况下仍会发生泵血栓。我们报告了 5 名植入连续流动离心式左心室辅助装置的患者的危险因素、非手术治疗以及泵内血栓形成的临床、血流动力学和实验室特征。这些信息可能支持在这些新一代设备中对疑似泵血栓使用静脉溶栓药物。
