Kontsas Konstantinos, Triantafyllidi Helen, Trivilou Paraskevi, Ikonomidis Ignatios, Tzortzis Stavros, Liazos Ioannis, Alevras Panagiotis, Paraskevaidis Ioannis, Kremastinos Dimitrios, Anastasiou-Nana Maria, Lekakis John
Laboratory of Cardiopulmonary Exercise Testing, 2nd Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital , Athens , Greece.
Blood Press. 2013 Oct;22(5):290-6. doi: 10.3109/08037051.2012.759694. Epub 2013 Feb 1.
Cardiopulmonary fitness is associated with reduced cardiovascular risk. Abnormal systolic blood pressure (SBP) response during recovery has been found to have diagnostic role for detecting cardiovascular risk. Aim of the study was to determine whether increased arterial stiffness associates with reduced aerobic exercise capacity after maximal cardiopulmonary exercise test (CPET) in a cohort of recently diagnosed hypertensive patients with a delayed decline in SBP during recovery.
Eighty-four hypertensive patients with recently diagnosed I-II essential hypertension and under treatment with RAAS antagonists ± HCTZ, underwent pulse wave velocity (PWV) estimation and a maximal CPET. Fifty-four healthy normotensive subjects served as a control group. Blood pressure recovery ratio (BPRR) was defined as the SBP after 3 min recovery divided by SBP at peak exercise.
PWV was significantly increased in hypertensives vs normotensives (p < 0.001). A non-independent, reverse association between PWV and VO2PEAK was revealed in hypertensives with delayed BPRR (r = - 0.49, p < 0.05). Age and sex independently predicted VO2PEAK in hypertensives with delayed BPRR.
Delayed blood pressure response detected during recovery in treated hypertensives implies a reverse relationship between any given impaired aerobic exercise capacity and expected persistent peripheral vascular resistance during exercise.
心肺适能与降低心血管风险相关。已发现恢复期间异常的收缩压（SBP）反应对检测心血管风险具有诊断作用。本研究的目的是确定在一组近期诊断为高血压且恢复期间SBP下降延迟的患者中，动脉僵硬度增加是否与最大心肺运动试验（CPET）后有氧运动能力降低相关。
84例近期诊断为I-II级原发性高血压且正在接受RAAS拮抗剂±氢氯噻嗪治疗的高血压患者，进行了脉搏波速度（PWV）评估和最大CPET。54名健康血压正常的受试者作为对照组。血压恢复率（BPRR）定义为恢复3分钟后的SBP除以运动峰值时的SBP。
与血压正常者相比，高血压患者的PWV显著升高（p < 0.001）。在BPRR延迟的高血压患者中，PWV与VO2PEAK之间存在非独立的反向关联（r = - 0.49，p < 0.05）。年龄和性别独立预测BPRR延迟的高血压患者的VO2PEAK。
在接受治疗的高血压患者恢复期间检测到的血压反应延迟意味着任何给定的有氧运动能力受损与运动期间预期的持续外周血管阻力之间存在反向关系。
