通过 In(III)催化的 6-endo- dig 环化异构化快速合成菲。
Expedient synthesis of phenanthrenes via In(III)-catalyzed 6-exo-dig cycloisomerization.
机构信息
College of Pharmacy, Seoul National University, San 56-1, Shilim, Kwanak, Seoul 151-742, Korea.
出版信息
Org Lett. 2013 Feb 15;15(4):920-3. doi: 10.1021/ol400073s. Epub 2013 Feb 1.
PMID:23373705
Abstract
This paper documents the first example of In(III)-catalyzed selective 6-exo-dig hydroarylation of o-propargylbiaryls and their subsequent double-bond migration to obtain functionalized phenanthrenes. Electron-rich biaryl substrates undergo hydroarylation more effectively, and the substrates with various types of substituents on the alkyne can also be smoothly and selectively converted to phenanthrenes.
摘要
本文记录了首例 In(III)催化的邻炔基联苯的选择性 6-endo-dig 氢芳基化反应，以及随后的双键迁移得到官能化菲。富电子联苯底物的氢芳基化反应更有效，炔基上带有各种取代基的底物也能顺利且选择性地转化为菲。
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