三氟甲磺酸铟催化的α-苯基烯丙基β-酮砜的分子内氢芳基化反应——磺酰基-1-苯并环庚酮和1-四氢萘酮的合成
In(OTf)-catalyzed intramolecular hydroarylation of α-phenylallyl β-ketosulfones - synthesis of sulfonyl 1-benzosuberones and 1-tetralones.
作者信息
Chang Meng-Yang, Lai Kai-Xiang, Chang Yu-Lun
机构信息
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung 80708 Taiwan
出版信息
RSC Adv. 2020 May 13;10(31):18231-18244. doi: 10.1039/d0ra01962c. eCollection 2020 May 10.
In(OTf)-catalyzed intramolecular hydroarylation of α-phenylallyl β-ketosulfones provides sulfonyl 1-benzosuberones and 1-tetralones in moderate to good yields in refluxing (CHCl) under open-vessel and easy-operation reaction conditions. A plausible mechanism is proposed and discussed. This highly regioselective protocol provides an atom-economic ring-closure route.
三氟甲磺酸铟催化的α-苯基烯丙基β-酮砜的分子内氢芳基化反应，在开放容器和易于操作的反应条件下，于回流的氯仿中以中等至良好的产率得到磺酰基-1-苯并环庚酮和1-四氢萘酮。提出并讨论了一种合理的反应机理。该高度区域选择性的方法提供了一条原子经济的闭环路线。
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