Negulesco J A, Noel S A, Delphia J M, Boggs M T, Davis D H
Department of Anatomy, College of Medicine, Ohio State University, Columbus 43210.
Artery. 1990;17(3):144-58.
In this study adult male CF-1 mice were treated on a daily basis as follows: Group A - controls, Group B - ethanol (ET) treated (1.25 g ET/kg body weight (b.wt.], Group C - ET plus 4 mg Capsaicin (C)/kg b.wt., and Group D - ET plus 4 mg dihydrocapsaicin (DC)/kg b.wt. At the end of the sixth week experimental period the animals were anesthetized, exsanguinated and hepatectomized. Our study suggests that ET administered at the rate of 1.25 g ET/kg b.wt. reaches a mean serum value of 43 + 14 mg/dL within 15 minutes. In addition, chronic ET ingestion significantly decreases mean hepatic glycogen content and mean serum triglyceride concentration of the animals. Conjoint administration of ET plus C decreases significantly mean body weight and mean ET and the triglyceride concentration of the serum. Prolonged ET ingestion plus DC administration decreases mean wet liver weight and lowers significantly the mean serum ET, cholesterol and triglyceride concentrations of CF-1 mice.
在本研究中，成年雄性CF-1小鼠每天按如下方式处理：A组为对照组，B组用乙醇（ET）处理（1.25 g ET/千克体重），C组用ET加4毫克辣椒素（C）/千克体重处理，D组用ET加4毫克二氢辣椒素（DC）/千克体重处理。在六周的实验期结束时，将动物麻醉、放血并进行肝切除。我们的研究表明，以1.25 g ET/千克体重的剂量给药ET，15分钟内血清平均值达到43±14毫克/分升。此外，长期摄入ET会显著降低动物的平均肝糖原含量和平均血清甘油三酯浓度。ET与C联合给药会显著降低平均体重以及血清中ET和甘油三酯的浓度。长期摄入ET并给予DC会降低肝脏湿重，并显著降低CF-1小鼠的平均血清ET、胆固醇和甘油三酯浓度。
