Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
Viral Immunol. 2013 Feb;26(1):109-13. doi: 10.1089/vim.2012.0052. Epub 2013 Feb 1.
Unlike the polymorphic MHC class Ia molecules, MHC class Ib molecules are oligomorphic or nonpolymorphic. We recently discovered a protective CD8 T cell response to mouse polyomavirus (MPyV) in H-2(b) haplotype mice that is restricted by H2-Q9, a member of the Qa-2 MHC class Ib family. Here, we demonstrate that immunization with a peptide corresponding to a virus capsid-derived peptide presented by Q9 also elicits MHC class Ib-restricted MPyV-specific CD8 T cells in mice of H-2(s) and H-2(g7) strains. These findings support the concept that immunization with a single MHC class Ib-restricted peptide can expand CD8 T cells in MHC class Ia allogeneic hosts.
与多态 MHC Ⅰ类分子不同，MHC Ⅰ类分子是低多态性或非多态性的。我们最近发现，在 H-2(b)单倍型小鼠中存在针对小鼠多瘤病毒（MPyV）的保护性 CD8 T 细胞反应，该反应受 Qa-2 MHC Ⅰ类家族成员 H2-Q9 的限制。在这里，我们证明用对应于由 Q9 呈递的病毒衣壳衍生肽的肽进行免疫接种也会在 H-2(s)和 H-2(g7)品系的小鼠中引发 MHC Ⅰ类限制的 MPyV 特异性 CD8 T 细胞。这些发现支持这样的概念，即用单一 MHC Ⅰ类限制肽进行免疫接种可以在 MHC Ⅰ类同种异体宿主中扩增 CD8 T 细胞。
