Center for Cardiovascular Innovation, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Ann Thorac Surg. 2013 Mar;95(3):876-83. doi: 10.1016/j.athoracsur.2012.11.041. Epub 2013 Jan 29.
Heart transplantation requires substantial personal, financial, and psychosocial resources. Using an existing multisite data set, we examined predictors of mortality at 5 to 10 years after heart transplantation.
All 555 participants completed a self-report quality of life instrument. Of these patients, 55 (10%) died 5 to 10 years after heart transplantation. Statistical analyses included frequencies, means, Pearson correlation coefficients, and Cox proportional hazard modeling.
Educational level and higher levels of social and economic satisfaction were predictive of improved survival. Conversely, married status, more cumulative infections, the presence of hematologic disorders, higher New York Heart Association (NYHA) class, and poor adherence to medical care predicted worse survival.
Demographic, clinical, psychosocial, and behavioral factors were important predictors of long-term survival after heart transplantation. These findings have important implications for patient selection for heart transplantation, as well as for posttransplantation care.
心脏移植需要大量的个人、财务和社会心理资源。我们利用现有的多站点数据集，研究了心脏移植后 5 至 10 年死亡率的预测因素。
所有 555 名参与者都完成了一份自我报告的生活质量量表。在这些患者中，有 55 名（10%）在心脏移植后 5 至 10 年内死亡。统计分析包括频率、平均值、皮尔逊相关系数和 Cox 比例风险模型。
教育程度和更高水平的社会经济满意度是生存改善的预测因素。相反，已婚状态、更多的累积感染、血液系统疾病的存在、更高的纽约心脏协会（NYHA）分级以及对医疗保健的不良依从性预示着更差的生存。
人口统计学、临床、社会心理和行为因素是心脏移植后长期生存的重要预测因素。这些发现对心脏移植的患者选择以及移植后的护理具有重要意义。
