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[耳鸣在耳毒性的诊断和预后中的作用]

[Tinnitus in the diagnosis and prognosis of ototoxicity].

作者信息

Doménech J, Carulla M, Traserra J

机构信息

Cátedra de ORL, Facultad de Medicina, Universidad de Barcelona.

出版信息

Acta Otorrinolaringol Esp. 1990 Jan-Feb;41(1):7-9.

PMID:2337487
Abstract

The prognostic value of tinnitus about the occurrence of hypoacusia in a patient undergoing an ototoxic treatment is not know. Ninety-five patients treated with cisplatinum, a cocleotoxic drug, have been studied to evaluate the percentage of patients with tinnitus, to assess the characteristics of these tinnitus and to know if there is a relationship between its occurrence and the degree of hearing loss that appears after treatment. Thirty-six patients (37.9%) had tinnitus, and there was not a statistically significant relationship between this symptom and the hearing loss. Therefore, tinnitus cannot be used as a prognostic factor for hypoacusia in patients undergoing treatment with cisplatinum.

摘要

耳鸣对于接受耳毒性治疗患者发生听力减退的预后价值尚不清楚。我们对95例接受顺铂(一种耳毒性药物)治疗的患者进行了研究,以评估耳鸣患者的比例,评估这些耳鸣的特征,并了解耳鸣的发生与治疗后出现的听力损失程度之间是否存在关联。36例患者(37.9%)有耳鸣,且该症状与听力损失之间无统计学显著关联。因此,耳鸣不能用作接受顺铂治疗患者听力减退的预后因素。

相似文献

1
[Tinnitus in the diagnosis and prognosis of ototoxicity].[耳鸣在耳毒性的诊断和预后中的作用]
Acta Otorrinolaringol Esp. 1990 Jan-Feb;41(1):7-9.
2
Ototoxicity in patients receiving cisplatin: importance of dose and method of drug administration.接受顺铂治疗患者的耳毒性:药物剂量和给药方法的重要性。
Cancer Treat Rep. 1982 Jan;66(1):19-23.
3
A review of cis-platinum ototoxicity.顺铂耳毒性综述。
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4
Cisplatin-based chemotherapy: Add high-frequency audiometry in the regimen.基于顺铂的化疗:在治疗方案中增加高频听力测定。
Indian J Cancer. 2009 Oct-Dec;46(4):311-7. doi: 10.4103/0019-509X.55551.
5
[Ototoxic side effects in patients with ovarian cancer treated with cisplatin].
Zentralbl Gynakol. 1988;110(5):277-82.
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Neurochemistry of the peripheral and central auditory system after ototoxic drug exposure: implications for tinnitus.耳毒性药物暴露后外周和中枢听觉系统的神经化学:对耳鸣的影响
Int Tinnitus J. 2005;11(1):23-30.
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[Detection of late ototoxic side effect of cisplatin by distortion otoacoustic emission (DPOAE)].[通过畸变产物耳声发射(DPOAE)检测顺铂的迟发性耳毒性副作用]
Magy Onkol. 2006;50(4):329-35. Epub 2007 Jan 10.
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Factors affecting sensitivity of distortion-product otoacoustic emissions to ototoxic hearing loss.影响畸变产物耳声发射对耳毒性听力损失敏感性的因素。
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Ototoxicity from high-dose use of platinum compounds in patients with neuroblastoma.神经母细胞瘤患者大剂量使用铂类化合物导致的耳毒性。
Cancer. 2006 Jul 15;107(2):417-22. doi: 10.1002/cncr.22004.
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[Prevention and treatment of toxic and adverse effects of cisplatin].
Zhonghua Fu Chan Ke Za Zhi. 1995 Jun;30(6):376-9.

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Analysis of risk factors for cisplatin-induced ototoxicity in patients with testicular cancer.睾丸癌患者顺铂诱导耳毒性的危险因素分析。
Br J Cancer. 1998 Apr;77(8):1355-62. doi: 10.1038/bjc.1998.226.