Cardio-Thoracic Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi, China.
Asian Pac J Trop Med. 2013 Mar;6(3):237-41. doi: 10.1016/S1995-7645(13)60031-0.
To explore the feasibility of establishing an animal model of chronic radiation-induced lung injury.
Twenty-eight New Zealand white rabbits were randomly divided into 3 groups (the right lung irradiation group, the whole lung irradiation group and the control group). Animal model of radiation-induced lung injury was established by high-does radiotherapy in the irradiation groups, then all rabbits underwent CT and pathological examinations at 1, 2, 4, 8, 12, 16 weeks, respectively after radiation.
Within 4 weeks of irradiation, some rabbits in the right lung irradiation group and whole lung irradiation group died. CT and pathological examinations all showed acute radiation pneumonitis. At 8-12 weeks after irradiation, CT scanning showed ground glass samples signs, patchy shadows and fibrotic stripes. Pathological examination showed the fibrosis pulmonary alveolar wall thickened obviously.
The clinical animal model of chronic radiation-induced lung injury which corresponds to practical conditions in clinic can be successfully established.
探索建立慢性放射性肺损伤动物模型的可行性。
将 28 只新西兰大白兔随机分为 3 组（右肺照射组、全肺照射组和对照组）。照射组采用高剂量放疗建立放射性肺损伤动物模型，然后分别于照射后 1、2、4、8、12、16 周对所有兔子进行 CT 和病理检查。
照射后 4 周内，部分右肺照射组和全肺照射组的兔子死亡。CT 和病理检查均显示急性放射性肺炎。照射后 8-12 周，CT 扫描显示磨玻璃样征、斑片状影和纤维性条纹。病理检查显示纤维化肺泡壁明显增厚。
成功建立了符合临床实际情况的慢性放射性肺损伤临床动物模型。
